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Santiago Ramón y Cajal

Santiago Ramón y Cajal

Current positions

Academic Qualifications

  • Degree in Medicine and Surgery from the University of Zaragoza, 1982
  • Doctorate in Medicine and Surgery from the Faculty of Medicine, University of Zaragoza
  • Specialization in Histopathology at the Jiménez Díaz Foundation, Madrid

Areas of Research

  • Tumors pathology
  • Study of new diagnostic and prognostic markers in cancer
  • Molecular pathology
  • Study of cell signaling pathway in human tumors. Identification of funnel factors
  • Study of gene expression of senescence in human tumors

Prizes and Scholarships

  • Rhone-Poulenc-Rorer Award of the Association for Cancer Research, 1996
  • Ernesto Seco Award of the Royal National Academy of Medicine, 1996
  • Member of Honor of the College of Physicians of Zaragoza, 1997
  • National Award for Research in Oncology for young investigators (1997), International Research Promotion Council (IRPC) Award for “Eminent Scientist of the Year 1999”
  • IRPC Gold Medal
  • Corresponding Academic of the Royal National Academy of Medicine, 2001
  • Honorary Academic of the Royal Academy of Medicine of Andalusia, 2006
  • Scholarship from the National Training Plan for Research Personnel, 1983 and 1984
  • Scholarship from the Social Security Health Care Research Fund, 1989-1990. Postdoctoral Fellow at the Pathology Department of Yale
    University (USA), 1989-90.

Most relevant scientific publications

  • Pedersen K, Angelini PD, Laos S, Bach-Faig A, Cunningham MP, Ferrer-Ramón C, Luque-García A, García-Castillo J, Parra-Palau JL, Scaltriti M, Ramón y Cajal S, Baselga J, Arribas J. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol. Cell. Biol. 2009 Jun; 29(12): 3319-31
  • Scaltriti M, Verma C, Guzman M, Jimenez J, Parra JL, Pedersen K, Smith DJ, Landolfi S, Ramón y Cajal S, Arribas J, Baselga J. Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity. Oncogene 2009 Feb; 28(6): 803-14
  • Monge M, Doll A, Colas E, Gil-Moreno A, Castellví J, Garcia A, Colomé N, Perez-Benavente A, Pedrola N, Lopez-Lopez R, Dolcet X, Ramón y Cajal S, Xercavins J, Matias-Guiu X, Canals F, Reventos J, Abal M. Subtractive proteomic approach to the endometrial carcinoma invasion front. J. Proteome Res. 2009 Oct; 8(10): 4676-84
  • Benavente S, Verges R, Hermosilla E, Fumanal V, Casanova N, Garcia A, Ramón y Cajal S, Giralt J. Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2009 Dec; 75(5): 1316-22
  • Bielanska J, Hernandez-Losa J, Pérez-Verdaguer M, Moliné T, Somoza R, Ramón y Cajal S, Condom E, Ferreres JC, Felipe A. Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human cancer. Curr Cancer Drug Targets 2009 Dec; 9(8): 904-14
  • Dopeso H, Mateo-Lozano S, Mazzolini R, Rodrigues P, Lagares-Tena L, Ceron J, Romero J, Esteves M, Landolfi S, Hernandez-Losa J, Castaño J, Wilson AJ, Ramón y Cajal S, Mariadason JM, Schwartz S, Arango D. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res. 2009 Sep; 69(18): 7430-8
  • López-Vicente L, Armengol G, Pons B, Coch L, Argelaguet E, Lleonart M, Hernandez-Losa J, de Torres I, Ramón y Cajal S. Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors. Clin. Cancer Res. 2009 Jul; 15(14): 4546-53
  • Albanell J, Andreu X, Calasanz MJ, Concha A, Corominas JM, García-Caballero T, López JA, López-Ríos F, Ramón y Cajal S, Vera-Sempere FJ, Colomer R, Martín M, Alba E, González-Martin A, Llombart A, Lluch A, Palacios J. Guidelines for HER2 testing in breast cancer: a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM). Clin Transl Oncol 2009 Jun; 11(6): 363-75
  • Castellví J, Garcia A, Ruiz-Marcellan C, Hernandez-Losa J, Peg V, Salcedo M, Gil-Moreno A, Ramón y Cajal S. Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis. Hum. Pathol. 2009 Oct; 40(10): 1418-26

All publications