Proteomics Group

Exploring the role of ADAM and ADAMTS metalloproteases in cancer through proteomic analysis
Proteomic screening for new biomarkers to assist cancer therapeutics
Providing services in proteomic techniques to other research groups as core facility

Explore the role of ADAM and ADAMTS metalloproteases in tumor progression
Screening for new cell-surface markers of glioma-initiating cells
Implementing new quantitative proteomic analysis methodologies, such as iTRAQ and label-free strategies.
Continuing to provide service on state-of-the art proteomic methodologies to other research groups.

Team

Principal Investigator

Esselens C, Malapeira J, Colomé N, Casal C, Rodríguez-Manzaneque JC, Canals F, Arribas J. The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration. J. Biol. Chem. 2010 Jan; 285(4): 2463-73
García-Castillo J, Pedersen K, Angelini PD, Bech-Serra JJ, Colomé N, Cunningham MP, Parra-Palau JL, Canals F, Baselga J, Arribas J. HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation. J. Biol. Chem. 2009 Sep; 284(37): 25302-13
Bech-Serra JJ, Borthwick A, Colomé N, Albar JP, Wells M, Sánchez del Pino M, Canals F. A multi-laboratory study assessing reproducibility of a 2D-DIGE differential proteomic experiment. J Biomol Tech 2009 Dec; 20(5): 293-6
García-Ramírez M, Hernández C, Villarroel M, Canals F, Alonso MA, Fortuny R, Masmiquel L, Navarro A, García-Arumí J, Simó R. Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy. Diabetologia 2009 Dec; 52(12): 2633-41
Hellin JL, Bech-Serra JJ, Moctezuma EL, Chocron S, Santin S, Madrid A, Vilalta R, Canals F, Torra R, Meseguer A, Nieto JL. Very low-molecular-mass fragments of albumin in the plasma of patients with focal segmental glomerulosclerosis. Am. J. Kidney Dis. 2009 Nov; 54(5): 871-80