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Tumor Biomarkers Group
Strategic Goals
- The characterization of the mechanisms used by tumor cells to communicate with their microenvironment during tumorigenesis, and its exploitation for biomarker discovery.
- The discovery of secreted signaling pathway-based tumor biomarkers and therapeutic targets using quantitative proteomics.
- The discovery of secreted response/resistance biomarkers to targeted drug therapy measurable through non-invasive methods.
Team
Post-doctoral Fellows
- Josep Gregori Font, PhD
- Olga Méndez, PhD
- Laura Villarreal, PhD
Technician
- Candida Salvans
Publications
- Villanueva J, Nazarian A, Lawlor K, Tempst P. Monitoring peptidase activities in complex proteomes by MALDI-TOF mass spectrometry. Nat Protoc 2009; 4(8): 1167-83
- Lawlor K, Nazarian A, Lacomis L, Tempst P, Villanueva J. Pathway-based biomarker search by high-throughput proteomics profiling of secretomes. J. Proteome Res. 2009 Mar; 8(3): 1489-503
- Villanueva J, Nazarian A, Lawlor K, Yi SS, Robbins RJ, Tempst P. A sequence-specific exopeptidase activity test (SSEAT) for "functional" biomarker discovery. Mol. Cell Proteomics 2008 Mar; 7(3): 509-18
- Villanueva J, Philip J, DeNoyer L, Tempst P. Data analysis of assorted serum peptidome profiles. Nat Protoc 2007; 2(3): 588-602
- Villanueva J, Lawlor K, Toledo-Crow R, Tempst P. Automated serum peptide profiling. Nat Protoc 2006; 1(2): 880-91
