Home Event Chris Lord – Exploiting synthetic lethality in the design of new therapeutic approaches for cancer

Date

02 oct. 2020
Expired!

Time

12:00 pm - 1:00 pm

Chris Lord – Exploiting synthetic lethality in the design of new therapeutic approaches for cancer

VHIO -”la Caixa” Foundation SCIENTIFIC SEMINARS SERIES 

 

 

Identifying, understanding and exploiting PARP inhibitor and other synthetic lethal effects remains the focus of Prof. Lord’s work. This work includes efforts to identify the molecular features that predict response to therapy, identifying drug combination strategies that can maximise efficacy and understanding how drug resistance emerges. In addition to focussing on using a synthetic lethal approach to target BRCA-gene mutant cancers, Prof. Lord’s work also focusses on identifying and understanding synthetic lethal effects associated with other DNA repair defective cancers and well as those with E-cadherin, Rb or SWI/SNF defects.