Arkaitz Carracedo – Metabolic intricacies of prostate cancer
- Speaker: Arkaitz Carracedo, Principal Investigator of Cancer Cell Signaling And Metabolism Lab, CICbioGUNE, Bilbao, Spain
- Talk title: Metabolic intricacies of prostate cancer
- Date & time: Friday 15th January, 12:00h
- Host: Maria Abad, Principal Investigator of VHIO’s Cellular Plasticity and Cancer Group
Dr. Carracedo scientific career started and has always been related to a single question: What are the differences between normal and cancer cells that can allow us to develop more selective and effective therapies? During his undergraduate studies and later in his PhD thesis work, he approached this question by studying a family of compounds, cannabinoids, which show a high selectivity between normal and cancer cells. His work in the Guzman laboratory allowed them to uncover a novel signaling pathway that links cannabinoid receptor activation to endoplasmic reticulum stress-induced apoptosis, through a novel regulator, the stress protein p8. At the end of his period in Guzman laboratory, he had continued his work discovering that these compounds could regulate autophagy through the oncogenic PI3K-mTOR pathway, and in turn he became very interested in how this signaling pathway could influence cancer cell biology and the relevance of its pharmacological targeting in cancer. With this idea in mind, he joined Pier Paolo Pandolfi´s laboratory, at the time in Memorial Sloan Kettering Cancer Center, to continue his work from a different and innovative angle. He focused these years in studying the regulation and relevance of the oncogenic PI3K-mTOR pathway in cancer. On the one hand, he has contributed to increase the knowledge of how the tumor suppressor PTEN operates and its relevance in prostate cancer cell biology. On the other hand, he has contributed to define the means of regulation of the mTOR signaling node and the therapeutic opportunities that modulating this kinase could offer.