Home Event María Casanova-Acebes. Macrophage determinants for the initiation and progression of non-small-cell lung carcinoma

Date

09 abr. 2021
Expired!

Time

12:00 pm - 1:00 pm

María Casanova-Acebes. Macrophage determinants for the initiation and progression of non-small-cell lung carcinoma

  • Speaker: María Casanova-Acebes, Junior Group Leader at CNIO, Madrid, Spain
  • Talk title:  Macrophage determinants for the initiation and progression of non-small-cell lung carcinoma
  • Date & time: Friday, 9th April, 2021
  • Host: Maria Abad, Principal Investigator of VHIO’s Cellular Plasticity and Cancer Group.

She is a postdoctoral fellow at Tisch Cancer Institute in the laboratory of Dr. Miriam Merad. She received her PhD in Cellular
Biology and Genetics under the supervision of Dr. Andrés Hidalgo at the Universidad Autónoma de Madrid, Spain; which
was awarded the best PhD thesis in her Department in 2014-2015. Her PhD studies were focused in understanding
neutrophil aging mechanisms and how the removal of aged neutrophils triggers the homeostatic release of hematopoietic
progenitors from bone marrow into the blood. She joined Merad laboratory on April 2015 after being awarded a long-term
postdoctoral fellowship from the Human Frontiers Science Program, one of the most prestigious international grants for
postdoctoral researchers. During her PhD, she published in high impact journals (Cell, Nature Immunology) and received an
international EMBO short-term fellowship for PhD students. Her research has also been selected for oral presentations in
international meetings, and she have obtained several prizes for best oral presentation at these meetings. During her
postdoctoral research she is studying the role of macrophage ontogeny in the context of lung adenocarcinoma progression
in primary tumors. In her studies she discovered that embryonic and adult macrophages have a distinct temporal and spatial
distribution in the tumor microenvironment. Embryonic macrophages are the first cells that interact with tumor cells to
promote tumor invasiveness and early regulatory T cell induction. Ablating embryonic macrophages, while sparing adult
ones, significantly reversed Treg/Teff ratio and reduced tumor growth, highlighting the specialized function of ontogenically
distinct macrophages. Their study highlights the key contribution of embryonic macs to tumor outcome and uncovers novel
macrophage determinants of tumor immunity.

 

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