CFAH GRUPO DE CÁNCER DE MAMA Y MELANOMA – VHIO – Vall d'Hebron Institute of Oncology

GRUPO DE CÁNCER DE MAMA Y MELANOMA

INVESTIGACIÓN CLÍNICA
Grupo de Cáncer de Mama y Melanoma

CRISTINA SAURA
Investigador Principal
Biosketch

La principal área de especialización del Grupo de Cáncer de Mama liderado por Cristina Saura es la investigación clínica centrada en el desarrollo de fármacos y la investigación traslacional asociada. Además del elevado número de pacientes reclutados en nuestros estudios, también desempeñamos un papel de liderazgo en muchos de los ensayos clínicos que llevamos a cabo. Esto nos permite tener un impacto directo en la aplicación de datos traslacionales para guiar y acelerar el desarrollo de fármacos:

  • Enfermedad positiva para HER2: participamos en los principales ensayos que prueban terapias novedosas y los agentes más prometedores en nuestro campo, incluidos DS8201, tucatinib, neratinib y SYD985. En colaboración con el Grupo de Factores de Crecimiento del VHIO, encabezado por Joaquín Arribas, exploramos la resistencia de los medicamentos contra el cáncer a estos agentes a través de los modelos PDX establecidos internamente por el VHIO. Junto con el Grupo de Oncología Molecular de Paolo Nuciforo, nuestro objetivo es validar métodos más precisos para cuantificar la expresión de HER2.
  • Enfermedad luminal: en asociación con el Grupo de Tratamientos Experimentales del VHIO, encabezado por Violeta Serra, hemos desarrollado varios modelos de PDX para avanzar en nuestra comprensión de los mecanismos de resistencia a varios fármacos y cómo pueden revertirse mediante el tratamiento con PI3K, AKT, CDK4/6, e inhibidores de BET, así como nuevos SERD orales y diferentes inhibidores de PARP.
  • Enfermedad triple negativa: además de nuestra participación en ensayos clínicos que prueban combinaciones de inmunoterapias, estamos colaborando en proyectos pioneros centrados en terapias celulares dirigidos por Alena Gros, investigadora principal del Grupo de Inmunología Tumoral e Inmunoterapia del VHIO, para desarrollar nuevas terapias personalizadas de linfocitos T contra el cáncer.
  • ADNlc: en colaboración con el Grupo de Genómica del Cáncer del VHIO, liderado por Ana Vivancos, hemos analizado la concordancia de alteraciones genómicas en biopsias tumorales sincrónicas y ADNtc de pacientes con cáncer de mama metastásico. Ahora estamos participando en varios proyectos para abordar el complejo contexto de la enfermedad temprana y la identificación del ADNlc en muestras biológicas inexploradas, incluida la leche materna.

Nuestro Grupo de Melanoma y otros Tumores Cutáneos está liderado por Eva Muñoz. Ha participado activamente en varios ensayos de fase I, II y III centrados en el melanoma y otros tumores de piel para estudiar diversas terapias emergentes para el tratamiento de estas enfermedades. Este grupo lidera su propio programa de investigación, que incorpora a investigadores clínicos, dermatólogos e investigadores de oncología del VHIO.

Los estudios del equipo se centran en nuevas terapias diana y la resistencia a la inmunoterapia mediante la realización de una investigación puramente traslacional centrada en el melanoma, la adquisición de resistencia al carcinoma epidermoide y basocelular y la progresión de la enfermedad. Sus esfuerzos también se centran en el mapeo de nuevas vías terapéuticas, el seguimiento de los estándares y la identificación de biomarcadores para una selección de tratamiento más precisa que coincida con las especificidades de nuestros pacientes.

OBJETIVOS ESTRATÉGICOS

  • Mama:
    • Optimizar las terapias mediante la introducción de nuevos tratamientos antineoplásicos y la agregación de combinaciones racionales para combatir los mecanismos de resistencia.
    • Incorporar plataformas de proteómica, genómica y ADNlc en la investigación traslacional para avanzar en la comprensión de la biología tumoral.
    • Aplicar datos preclínicos y predictivos para ayudar a guiar el diseño de ensayos clínicos innovadores en enfermedades avanzadas.

    Melanoma:

    • Nuestra Unidad de Melanoma encabeza una de las mayores redes de España y de Europa, y es también una de las más activas en ensayos clínicos metastásicos y adyuvantes en melanoma y otros tumores cutáneos. Cada ensayo está estrechamente relacionado con las correspondientes líneas de investigación traslacional lideradas por científicos del VHIO.
    • Aprovechar el papel de la secreción no clásica vinculada a la invasión tumoral y la metástasis para identificar biomarcadores y dianas terapéuticas contra el cáncer de mama.
    • Caracterizar el papel de la HMGA1 extracelular en la invasión y metástasis del cáncer de mama.
    • Caracterización de los mecanismos adoptados por las células tumorales para comunicarse con su microambiente durante el tratamiento para establecer biomarcadores secretados de respuesta/resistencia a las terapias farmacológicas contra el cáncer.

ASPECTOS DESTACADOS

  • Contribuciones relevantes a la autorización de medicamentos: gracias a la posición de liderazgo de nuestros investigadores, hemos contribuido a la autorización de medicamentos como neratinib en el entorno avanzado. Actualmente estamos implicados en el desarrollo de algunas de las terapias más prometedoras que serán autorizadas en un futuro cercano, incluyendo tucatinib y DS8201.
  • Medicina de precisión: gracias al programa de preselección interno del VHIO, seguimos identificando pacientes potenciales con alteraciones moleculares como estrategia de enriquecimiento para ensayos clínicos con las mutaciones PI3K, ESR1 o HER2. Las plataformas de proteómica y ADNlc de nuestro Instituto también nos han ayudado a avanzar en la comprensión de la biología tumoral.

EQUIPO

  • Investigador Principal
    • Cristina Saura
  • Médicos Oncólogos y Becarios de Investigación
    • Fabiola Amair
    • Miriam Arumí
    • Analia Azaro
    • Judith Balmaña
    • Meritxell Bellet
    • Marta Capelan
    • Santiago Escrivá
    • Laia Garrigos
    • Patricia Gómez
    • Eva Muñoz
    • Mafalda Oliveira
    • Carolina Ortiz
    • Isabel Pimentel
    • Esther Zamora
  • Especialista en Enfermería Clínica
    • Anna Suñol
  • Técnico
    • Nuria Duran

Publicaciones científicas más relevantes

  • Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer. N Engl J Med. 2020 Feb 13;382(7):610-621. doi: 10.1056/NEJMoa1914510. Epub 2019 Dec 11.
  • Murthy RK, Loi S, Okines A, Paplomata E, Hamilton E, Hurvitz SA, Lin NU, Borges V, Abramson V, Anders C, Bedard PL, Oliveira M, Jakobsen E, Bachelot T, Shachar SS, Müller V, Braga S, Duhoux FP, Greil R, Cameron D, Carey LA, Curigliano G, Gelmon K, Hortobagyi G, Krop I, Loibl S, Pegram M, Slamon D, Palanca-Wessels MC, Walker L, Feng W, Winer EP. Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer. N Engl J Med. 2020 Feb 13;382(7):597-609. doi: 10.1056/NEJMoa1914609. Epub 2019 Dec 11. Erratum in: N Engl J Med. 2020 Feb 6;382(6):586.
  • Prat A, Saura C, Pascual T, Hernando C, Muñoz M, Paré L, González Farré B, Fernández PL, Galván P, Chic N, González Farré X, Oliveira M, Gil-Gil M, Arumi M, Ferrer N, Montaño A, Izarzugaza Y, Llombart-Cussac A, Bratos R, González Santiago S, Martínez E, Hoyos S, Rojas B, Virizuela JA, Ortega V, López R, Céliz P, Ciruelos E, Villagrasa P, Gavilá J. Ribociclib plus letrozole versus chemotherapy for postmenopausal women with hormone receptor-positive, HER2-negative, luminal B breast cancer (CORALLEEN): an open-label, multicentre, randomised, phase 2 trial. Lancet Oncol. 2020 Jan;21(1):33-43. doi: 10.1016/S1470-2045(19)30786-7. Epub 2019 Dec 11.
  • Hyman DM, Piha-Paul SA, Won H, Rodon J, Saura C, Shapiro GI, Juric D, Quinn DI, Moreno V, Doger B, Mayer IA, Boni V, Calvo E, Loi S, Lockhart AC, Erinjeri JP, Scaltriti M, Ulaner GA, Patel J, Tang J, Beer H, Selcuklu SD, Hanrahan AJ, Bouvier N, Melcer M, Murali R, Schram AM, Smyth LM, Jhaveri K, Li BT, Drilon A, Harding JJ, Iyer G, Taylor BS, Berger MF, Cutler RE Jr, Xu F, Butturini A, Eli LD, Mann G, Farrell C, Lalani AS, Bryce RP, Arteaga CL, Meric-Bernstam F, Baselga J, Solit DB. HER kinase inhibition in patients with HER2- and HER3-mutant cancers. Nature. 2018 Feb 8;554(7691):189-194.
  • Rius Ruiz I, Vicario R, Morancho B, Morales CB, Arenas EJ, Herter S, Freimoser-Grundschober A, Somandin J, Sam J, Ast O, Barriocanal ÁM, Luque A, Escorihuela M, Varela I, Cuartas I, Nuciforo P, Fasani R, Peg V, Rubio I, Cortés J, Serra V, Escriva-de-Romani S, Sperinde J, Chenna A, Huang W, Winslow J, Albanell J, Seoane J, Scaltriti M, Baselga J, Tabernero J, Umana P, Bacac M, Saura C, Klein C, Arribas J. p95HER2-T cell bispecific antibody for breast cancer treatment. Sci Transl Med. 2018 Oct 3;10(461).
  • Francis  PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Láng I, Gómez HL, Tondini C, Ciruelos E, Burstein HJ, Bonnefoi HR, Bellet M, Martino S, Geyer CE Jr, Goetz MP, Stearns V, Pinotti G, Puglisi F, Spazzapan S, Climent MA, Pavesi L, Ruhstaller T, Davidson NE, Coleman R, Debled M, Buchholz S, Ingle JN, Winer EP, Maibach R, Rabaglio-Poretti M, Ruepp B, Di Leo A, Coates AS, Gelber RD, Goldhirsch A, Regan MM. N Engl J Med. 2018 Jul 12;379(2):122-137.
  • Sánchez-Danés A, Larsimont JC, Liagre M, Muñoz-Couselo E, Lapouge G, Brisebarre A, Dubois C, Suppa M, Sukumaran V, Del Marmol V, Tabernero J, Blanpain C. A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy. Nature. 2018 Oct;562(7727):434-438.
  • Saura C, Roda D, Roselló S, Oliveira M, Macarulla T, Pérez-Fidalgo JA, Morales-Barrera R, Sanchis-García JM, Musib L, Budha N, Zhu J, Nannini M, Chan WY, Sanabria Bohórquez SM, Meng RD, Lin K, Yan Y, Patel P, Baselga J, Tabernero J, Cervantes A. A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors. Cancer Discov.2017 Jan;7(1):102-113.
  • Llombart-Cussac A, Cortés J, Paré L, Galván P, Bermejo B, Martínez N, Vidal M, Pernas S, López R, Muñoz M, Nuciforo P, Morales S, Oliveira M, de la Peña L, Peláez A, Prat A. HER2-enriched subtype as a predictor of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer (PAMELA): an open-label, single-group, multicentre, phase 2 trial. Lancet Oncol. 2017 Apr;18(4):545-554.
  • Dickler MN, Tolaney SM, Rugo HS, Cortés J, Diéras V, Patt D, Wildiers H, Hudis CA, O’Shaughnessy J, Zamora E, Yardley DA, Frenzel M, Koustenis A, Baselga J. MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR+/HER2- Metastatic Breast Cancer. Clin Cancer Res. 2017 Sep 1;23(17):5218-5224.
  • Pérez-Alea M, McGrail K, Sánchez-Redondo S, Ferrer B, Fournet G, Cortés J, Muñoz E, Hernandez-Losa J, Tenbaum S, Martin G, Costello R, Ceylan I, Garcia-Patos V, Recio JA. ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment. Oncogene. 2017 Oct 12;36(41):5695-5708.
  • Bellet M, Gray KP, Francis PA, Láng I, Ciruelos E, Lluch A, Climent MA, Catalán G, Avella A, Bohn U, González-Martin A, Ferrer R, Catalán R, Azaro A, Rajasekaran A, Morales J, Vázquez J, Fleming GF, Price KN, Regan MM. Twelve-Month Estrogen Levels in Premenopausal Women With Hormone Receptor-Positive BreastCancer Receiving Adjuvant Triptorelin Plus Exemestane or Tamoxifen in the Suppression of OvarianFunction Trial (SOFT): The SOFT-EST Substudy. J Clin Oncol. 2016 May 10;34(14):1584-93.
  • Bruna A, Rueda OM, Greenwood W, Batra AS, Callari M, Batra RN, Pogrebniak K, Sandoval J, Cassidy JW, Tufegdzic-Vidakovic A, Sammut SJ, Jones L, Provenzano E, Baird R, Eirew P, Hadfield J, Eldridge M, McLaren-Douglas A, Barthorpe A, Lightfoot H, O’Connor MJ, Gray J, Cortes J, Baselga J, Marangoni E, Welm AL, Aparicio S, Serra V, Garnett MJ, Caldas C. A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen AnticancerCompounds. Cell. 2016 Sep 22;167(1):260-274.e22.
  • Herrera-Abreu MT, Palafox M, Asghar U, Rivas MA, Cutts RJ, Garcia-Murillas I, Pearson A, Guzman M, Rodriguez O, Grueso J, Bellet M, Cortés J, Elliott R, Pancholi S, Baselga J, Dowsett M, Martin LA, Turner NC, Serra V. Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer. Cancer Res. 2016 Apr 15;76(8):2301-13.
  • Pérez-Alea M, Vivancos A, Caratú G, Matito J, Ferrer B, Hernandez-Losa J, Cortés J, Muñoz E, Garcia-Patos V, Recio JA. Genetic profile of GNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway. Oncotarget. 2016 May 10;7(19):28086-95.
  • Cortés J, Saura C, Bellet M, Muñoz-Couselo E, Ramírez-Merino N, Calvo V,Pérez J, Vidal M. HER2 and hormone receptor-positive breast cancer–blocking the  right target. Nat Rev Clin Oncol. 2011 May;8(5):307-11.
  • Córdoba O, Llurba E, Saura C, Rubio I, Ferrer Q, Cortés J, Xercavins J. Multidisciplinary approach to breast cancer diagnosed during pregnancy: Maternal and neonatal outcomes. Breast 2013 Aug;22(4):515-9.
  • Dienstmann R, Serpico D, Rodon J, Saura C, Macarulla T, Elez E, Alsina M, Capdevila J, Perez-Garcia J, Sánchez-Ollé G, Aura C, Prudkin L, Landolfi S, Hernández-Losa J, Vivancos A, Tabernero J. Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials. Mol Cancer Ther. 2012 Sep;11(9):2062-71.
  • Rodón J, Saura C, Dienstmann R, Vivancos A, Ramón y Cajal S, Baselga J, Tabernero J. Molecular prescreening to select patient population in early clinical trials. Nat Rev Clin Oncol. 2012 Apr 3;9(6):359-66.
  • Modi S, Saura C, Henderson C, Lin NU, Mahtani R, Goddard J, Rodenas E, Hudis C, O’Shaughnessy J, Baselga J.  A multicentric trial evaluatin retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer. Breast Cancer Res Treat 2013 ;139 (1):107-13
  • Saura C, Tseng LM, Chan S, Chacko RT, Campone M, Manikhas A, Nag SM, Leichman CG, Dasappa L, Fasching PA, Hurtado de Mendoza F, Symmans WF, Liu D, Mukhopadhyay P, Horak C, Xing G, Pusztai L. Neoadjuvant doxorubicin/cyclophosphamide followed by ixabepilone or paclitaxel in early stage breast cancer and evaluation of βIII-tubulin expression as a predictive marker. Oncologist. 2013;18(7):787-94.
  • Yan Y, Serra V, Prudkin L, Scaltriti M, Murli S, Rodríguez O, Guzman M, Sampath D, Nannini M, Xiao Y, Wagle MC, Wu JQ, Wongchenko M, Hampton G, Ramakrishnan V, Lackner MR, Saura C, Roda D, Cervantes A, Tabernero J, Patel P, Baselga J. Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068. Clin Cancer Res. 2013  Dec 15;19(24):6976-86
  • Saura C, Bendell J, Jerusalem G, Su S, Ru Q, De Buck S, Mills D, Ruquet S, Bosch A, Urruticoechea A, Beck JT, Di Tomaso E, Sternberg DW, Massacesi C, Hirawat S, Dirix L, Baselga J. Phase Ib study of Buparlisib plus Trastuzumab in patients with HER2-positive advanced or metastatic breast cancer that has progressed on Trastuzumab-based therapy. Clin Cancer Res. 2014 Apr 1;20(7):1935-45.
  • Saura C, Garcia-Saenz JA, Xu B, Harb W, Moroose R, Pluard T, Cortés J, Kiger C, Germa C, Wang K, Martin M, Baselga J, Kim SB. Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2014 Nov 10;32(32):3626-33
  • Tolaney S, Burris H, Gartner E, Mayer IA, Saura C, Maurer M, Ciruelos E, García AA, Campana F, Wu B, Xu Y, Jiang J, Winer E, Krop I. Phase I/II study of pilaralisib (SAR245408) in combination with trastuzumab or trastuzumab plus paclitaxel in trastuzumab-refractory HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2015 Jan;149(1)151-61.

Todas las publicacions

  • Sanchez-Rovira, Pedro; Zamora, Pilar; Salvador-Bofill, Javier; Morales, Serafin; Martinez-Janez, Noelia; Martinez-de-Duenas, Eduardo; Lluch, Ana; Juan Illarramendi, Jose; GOMEZ PARDO, PATRICIA; Gavila Gregori, Joaquin; Garcia-Palomo, Andres; Garcia-Mata, Jesus; Fernandez, Yolanda; del Barco, Sonia; de Juan, Ana; Ciruelos, Eva; Ignacio Chacon, Jose; Calvo, Lourdes; Barnadas, Agusti; Albanell, Joan. Broad consensus on the optimal sequence for the systemic treatment of metastatic breast cancer: results from a survey of Spanish medical oncologists. Journal Of Drug Assessment. 2019 Apr 8;8(1):62-69. doi: 10.1080/21556660.2019.1604375. Rutgers, Emiel; BALMAÑA GELPI, JUDITH; Beishon, Marc; Benn, Karen; Evans, D. Gareth; Mansel, Robert; Pharoah, Paul; Skinner, Victoria Perry; Stoppa-Lyonnet, Dominique; Travado, Luzia; Wyld, Lynda. European Breast Cancer Council manifesto 2018: Genetic risk prediction testing in breast cancer. Eur J Cancer. 2019 Jan;106:45-53. doi: 10.1016/j.ejca.2018.09.019. Epub 2018 Nov 22.
  • Schmid, Peter; Zaiss, Matthias; Harper-Wynne, Catherine; Ferreira, Marta; Dubey, Sidharth; Chan, Stephen; Makris, Andreas; Nemsadze, Gia; Brunt, Adrian M; Kuemmel, Sherko; Ruiz, Isabel; Perelló, Antonia; Kendall, Anne; Brown, Janet; Kristeleit, Hartmut; Conibear, John; SAURA MANICH, CRISTINA; Grenier, Julien; Máhr, Károly; Schenker, Michael; Sohn, Joohyuk; Lee, Keun Seok; Shepherd, Christopher J; Oelmann, Elisabeth; Sarker, Shah-Jalal; Prendergast, Aaron; Marosics, Patricia; Moosa, Atiyyah; Lawrence, Cheryl; Coetzee, Carike; Mousa, Kelly; CORTES CASTAN, JAVIER. Fulvestrant Plus Vistusertib vs Fulvestrant Plus Everolimus vs Fulvestrant Alone for Women With Hormone Receptor-Positive Metastatic Breast Cancer: The MANTA Phase 2 Randomized Clinical Trial. JAMA Oncol. 2019 Aug 29. doi: 10.1001/jamaoncol.2019.2526.
  • Singer, Christian F.; BALMAÑA GELPI, JUDITH; Burki, Nicole; Delaloge, Suzette; Filieri, Maria Elisabetta; Gerdes, Anna-Marie; Grindedal, Eli Marie; Han, Sileni; Johansson, Oskar; Kaufman, Bella; Krajc, Mateja; Loman, Niklas; Olah, Edith; Paluch-Shimon, Shani; Plavetic, Natalija Dedic; Pohlodek, Kamil; Rhiem, Kerstin; Teixeira, Manuel; Evans, D. Gareth.Genetic counselling and testing of susceptibility genes for therapeutic decision-making in breast cancer-an European consensus statement and expert recommendations. Eur J Cancer. 2019 Jan;106:54-60. doi: 10.1016/j.ejca.2018.10.007
  • Chacón López-Muñiz, J I; de la Cruz Merino, L; Gavilá Gregori, J; Martínez Dueñas, E; ANTUNES DE MELO E OLIVEIRA, MAFALDA; Seguí Palmer, M A; Álvarez López, I; Antolin Novoa, S; BELLET EZQUERRA, MERITXEL; López-Tarruella Cobo, S. SEOM clinical guidelines in advanced and recurrent breast cancer (2018). Clin Transl Oncol. 2019 Jan;21(1):31-45. doi: 10.1007/s12094-018-02010-w.
  • Ignatiadis, Michail; Van den Eynden, Gert; Roberto, Salgado; Fornili, Marco; Bareche, Yacine; Desmedt, Christine; Rothé, Françoise; Maetens, Marion; Venet, David; Holgado, Esther; McNally, Virginia; Kiermaier, Astrid; Savage, Heidi M; Wilson, Timothy R; CORTES CASTAN, JAVIER; Schneeweiss, Andreas; Willard-Gallo, Karen; Biganzoli, Elia; Sotiriou, Christos. Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy. J Natl Cancer Inst. 2019 Jan 1;111(1):69-77. doi: 10.1093/jnci/djy076.
  • Gao, Meiling; Callari, Maurizio; Beddowes, Emma; Sammut, Stephen-John; Grzelak, Marta; Biggs, Heather; Jones, Linda; Boumertit, Abdelhamid; Linn, Sabine C; CORTES CASTAN, JAVIER; ANTUNES DE MELO E OLIVEIRA, MAFALDA; Baird, Richard; Chin, Suet-Feung; Caldas, Carlos.Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA. Genome Med. 2019 Jan 4;11(1):1. doi: 10.1186/s13073-018-0611-9.
  • Gavilá, Joaquín; ANTUNES DE MELO E OLIVEIRA, MAFALDA; Pascual, Tomás; Perez-Garcia, Jose; Gonzàlez, Xavier; Canes, Jordi; Paré, Laia; Calvo, Isabel; Ciruelos, Eva; Muñoz, Montserrat; Virizuela, Juan A; Ruiz, Isabel; Andrés, Raquel; Perelló, Antonia; Martínez, Jerónimo; Morales, Serafín; Marín-Aguilera, Mercedes; Martínez, Débora; Quero, Juan C; Llombart-Cussac, Antonio; Prat, Aleix. Safety, activity, and molecular heterogeneity following neoadjuvant non-pegylated liposomal doxorubicin, paclitaxel, trastuzumab, and pertuzumab in HER2-positive breast cancer (Opti-HER HEART): an open-label, single-group, multicenter, phase 2 trial. BMC Med. 2019 Jan 9;17(1):8. doi: 10.1186/s12916-018-1233-1.
  • MONTALBAN CANUDAS, GEMMA; BONACHE REAL, SANDRA; MOLES FERNANDEZ, ALEJANDRO; Gisbert-Beamud, Alexandra; TENES FELIPE, ANNA; Bach, Vanessa; CARRASCO LOPEZ, ESTELA; LOPEZ FERNANDEZ, ADRIA; STJEPANOVIC, NEDA; BALMAÑA GELPI, JUDITH; DIEZ GIBERT, ORLAND; GUTIERREZ ENRIQUEZ, SARA ILIANA.Screening of BRCA1/2 deep intronic regions by targeted gene sequencing identifies the first germline BRCA1 variant causing pseudoexon activation in a patient with breast/ovarian cancer. J Med Genet. 2019 Feb;56(2):63-74. doi: 10.1136/jmedgenet-2018-105606
  • Riveiro-Barciela, Mar; MUÑOZ COUSELO, EVA; Fernandez-Sojo, Jesús; Diaz-Mejia, Nely; Parra-López, Rafael; Buti, María. Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?. Journal of Hepatology 2019 vol. 70 j 548–577. Doi.org/10.1016/j.jhep.2018.10.020
  • Condorelli, R; Mosele, F; Verret, B; Bachelot, T; Bedard, P L; CORTES CASTAN, JAVIER; Hyman, D M; Juric, D; Krop, I; Bieche, I; SAURA MANICH, CRISTINA; Sotiriou, C; Cardoso, F; Loibl, S; Andre, F; Turner, N C. Genomic alterations in breast cancer: level of evidence for actionability according to ESMO Scale for Clinical Actionability of molecular Targets (ESCAT). Ann Oncol. 2019 Mar 1;30(3):365-373. doi: 10.1093/annonc/mdz036.
  • Ramos, Javier; Vega, Juan Francisco; Cruz, Victor; Sanchez-Sanchez, Eduardo; CORTES CASTAN, JAVIER; Martinez-Salazar, Javier. Hydrodynamic and Electrophoretic Properties of Trastuzumab/HER2 Extracellular Domain Complexes as Revealed by Experimental Techniques and Computational Simulations. Int J Mol Sci. 2019 Mar 1;20(5). pii: E1076. doi: 10.3390/ijms20051076.
  • Adams, S; Schmid, P; Rugo, H S; Winer, E P; Loirat, D; Awada, A; Cescon, D W; Iwata, H; Campone, M; Nanda, R; Hui, R; Curigliano, G; Toppmeyer, D; O’Shaughnessy, J; Loi, S; Paluch-Shimon, S; Tan, A R; Card, D; Zhao, J; Karantza, V; CORTES CASTAN, JAVIER. Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study. Ann Oncol. 2019 Mar 1;30(3):397-404. doi: 10.1093/annonc/mdy517.
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  • Perez-Garcia J, Muñoz-Couselo E, Soberino J, Racca F, Cortes J. Targeting FGFR pathway in breast cancer. Breast. 2018 Feb;37:126-133. doi: 10.1016/j.breast.2017.10.014.
  • Méndez O, Peg V, Salvans C, Pujals M, Fernández Y, Abasolo I, Pérez J, Matres A, Valeri M, Gregori J, Villarreal L, Schwartz S Jr, Ramon Y Cajal S, Tabernero J, Cortés J, Arribas J, Villanueva J.Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer. Clin Cancer Res. 2018 Dec 15;24(24):6367-6382. doi: 10.1158/1078-0432.CCR-18-0517. Epub 2018 Aug 22.
  • Sharma P, López-Tarruella S, García-Saenz JA, Khan QJ, Gómez HL, Prat A, Moreno F, Jerez-Gilarranz Y, Barnadas A, Picornell AC, Monte-Millán MD, González-Rivera M, Massarrah T, Pelaez-Lorenzo B, Palomero MI, González Del Val R, Cortés J, Fuentes-Rivera H, Morales DB, Márquez-Rodas I, Perou CM, Lehn C, Wang YY, Klemp JR, Mammen JV, Wagner JL, Amin AL, O’Dea AP, Heldstab J, Jensen RA, Kimler BF, Godwin AK, Martín M.Pathological Response and Survival in Triple-Negative Breast Cancer Following Neoadjuvant Carboplatin plus Docetaxel. Clin Cancer Res. 2018 Dec 1;24(23):5820-5829. doi: 10.1158/1078-0432.CCR-18-0585. Epub 2018 Jul 30.
  • Cortes J, Schöffski P, Littlefield BA.Multiple modes of action of eribulin mesylate: Emerging data and clinical implications. Cancer Treat Rev. 2018 Nov;70:190-198. doi: 10.1016/j.ctrv.2018.08.008. Epub 2018 Aug 21. Review.
  • Campone M, Im SA, Iwata H, Clemons M, Ito Y, Awada A, Chia S, Jagiełło-Gruszfeld A, Pistilli B, Tseng LM, Hurvitz S, Masuda N, Cortés J, De Laurentiis M, Arteaga CL, Jiang Z, Jonat W, Le Mouhaër S, Sankaran B, Bourdeau L, El-Hashimy M, Sellami D, Baselga J.Buparlisib plus fulvestrant versus placebo plus fulvestrant for postmenopausal, hormone receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer: Overall survival results from BELLE-2.Eur J Cancer. 2018 Nov;103:147-154. doi: 10.1016/j.ejca.2018.08.002. Epub 2018 Sep 18.
  • Cortes J, Pérez-García J, Whiting S, Wan Y, Solem C, Tai MH, Margunato-Debay S, Ko A, Fandi A, Botteman M.Quality-Adjusted Survival With nab-Paclitaxel Versus Standard Paclitaxel in Metastatic Breast Cancer: A Q-TWiST Analysis. Clin Breast Cancer. 2018 Oct;18(5):e919-e926. doi: 10.1016/j.clbc.2018.03.014. Epub 2018 Mar 30.
  • Schneeweiss A, Park-Simon TW, Albanell J, Lassen U, Cortés J, Dieras V, May M, Schindler C, Marmé F, Cejalvo JM, Martinez-Garcia M, Gonzalez I, Lopez-Martin J, Welt A, Levy C, Joly F, Michielin F, Jacob W, Adessi C, Moisan A, Meneses-Lorente G, Racek T, James I, Ceppi M, Hasmann M, Weisser M, Cervantes A.Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer. Invest New Drugs. 2018 Oct;36(5):848-859. doi: 10.1007/s10637-018-0562-4. Epub 2018 Jan 19.
  • Cortés J, Holgado E, Perez-Garcia J.CXCR4 antagonists for treatment of breast cancer.Oncotarget. 2018 Sep 11;9(71):33442-33443. doi: 10.18632/oncotarget.26090. eCollection 2018 Sep 11. No abstract available.
  • Holgado E, Perez-Garcia J, Gion M, Cortes J.Is there a role for immunotherapy in HER2-positive breast cancer? NPJ Breast Cancer. 2018 Aug 15;4:21. doi: 10.1038/s41523-018-0072-8. eCollection 2018. Review.
  • Traina TA, Cortes J.Reply to K.S. Shohdy et al. J Clin Oncol. 2018 Aug 10;36(23):2458-2459. doi: 10.1200/JCO.2018.78.8349. Epub 2018 May 30.
  • Rugo HS, Cortes J, Awada A, O’Shaughnessy J, Twelves C, Im SA, Hannah A, Lu L, Sy S, Caygill K, Zajchowski DA, Davis DW, Tagliaferri M, Hoch U, Perez EA.Change in Topoisomerase 1-Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol. Clin Cancer Res. 2018 Jul 15;24(14):3348-3357. doi: 10.1158/1078-0432.CCR-17-3059. Epub 2018 Apr 4.
  • Rugo HS, Cortes J.The new world of biosimilars in oncology: Translation of data to the clinic. Eur J Cancer. 2018 Jun;96:125-127. doi: 10.1016/j.ejca.2018.03.005. Epub 2018 Apr 18. No abstract available.
  • Pernas S, Martin M, Kaufman PA, Gil-Martin M, Gomez Pardo P, Lopez-Tarruella S, Manso L, Ciruelos E, Perez-Fidalgo JA, Hernando C, Ademuyiwa FO, Weilbaecher K, Mayer I, Pluard TJ, Martinez Garcia M, Vahdat L, Perez-Garcia J, Wach A, Barker D, Fung S, Romagnoli B, Cortes J.Balixafortide plus eribulin in HER2-negative metastatic breast cancer: a phase 1, single-arm, dose-escalation trial. Lancet Oncol. 2018 Jun;19(6):812-824. doi: 10.1016/S1470-2045(18)30147-5. Epub 2018 Apr 26.
  • Gonzalez-Cao M, Mayo de Las Casas C, Jordana Ariza N, Manzano JL, Molina-Vila MÁ, Soriano V, Puertolas T, Balada A, Soria A, Majem M, Montagut C, Muñoz E, Rodriguez-Abreu D, Perez E, Garcia A, Cortes J, Drozdowskyj A, Karachaliou N, Rosell R; Early evolution of BRAFV600 status in the blood of melanoma patients correlates with clinical outcome and identifies patients refractory to therapy.Spanish Melanoma Group. Melanoma Res. 2018 Jun;28(3):195-203. doi: 10.1097/ CMR.0000000000000432.
  • Traina TA, Miller K, Yardley DA, Eakle J, Schwartzberg LS, O’Shaughnessy J, Gradishar W, Schmid P, Winer E, Kelly C, Nanda R, Gucalp A, Awada A, Garcia-Estevez L, Trudeau ME, Steinberg J, Uppal H, Tudor IC, Peterson A, Cortes J.Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer. J Clin Oncol. 2018 Mar. 20;36(9):884-890. doi: 10.1200/JCO.2016.71.3495. Epub 2018 Jan 26.
  • Başaran GA, Twelves C, Diéras V, Cortés J, Awada A.Ongoing unmet needs in treating estrogen receptor-positive/HER2-negative metastatic breast cancer. Cancer Treat Rev. 2018 Feb;63:144-155. doi: 10.1016/ j.ctrv.2017.12.002. Epub 2017 Dec 6. Review.
  • Perez-Garcia J, Cortes J.Breast cancer in 2017: Spurring science, marking progress, and influencing history. Nat Rev Clin Oncol. 2018 Feb;15(2):79-80. doi: 10.1038/nrclinonc.2017.191. Epub 2017 Dec 12. No abstract available.
  • Schneeweiss A, Chia S, Hickish T, Harvey V, Eniu A, Waldron-Lynch M, Eng-Wong J, Kirk S, Cortés J.Long-term efficacy analysis of the randomised, phase II TRYPHAENA cardiac safety study: Evaluating pertuzumab and trastuzumab plus standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer. Eur J Cancer. 2018 Jan;89:27-35. doi: 10.1016 /j.ejca.2017.10.021. Epub 2017 Dec 8.
  • Palacios Calvo J, Albanell J, Rojo F, Ciruelos E, Aranda-López I, Cortés J, García-Caballero T, Martín M, López-García MÁ, Colomer R.Consensus statement on biomarkers in breast cancer by the Spanish Society of Pathology and the Spanish Society of Medical Oncology. Rev Esp Patol. 2018 Apr – Jun;51(2):97-109. doi: 10.1016/j.patol.2017.12.002. Epub 2018 Mar 14. Spanish.
  • Başaran GA, Twelves C, Diéras V, Cortés J, Awada A. Ongoing unmet needs in treating estrogen receptor-positive/HER2-negative metastatic breast cancer.Cancer Treat Rev. 2017 Dec 6;63:144-155
  • Cortés J, Im SA, Holgado E, Perez-Garcia JM, Schmid P, Chavez-MacGregor M. The next era of treatment for hormone receptor-positive, HER2-negative advanced breast cancer: Triplet combination-based endocrine therapies.Cancer Treat Rev. 2017 Dec;61:53-60
  • de Melo Gagliato D, Cortes J, Curigliano G, Loi S, Denkert C, Perez-Garcia J, Holgado E. Tumor-infiltrating lymphocytes in Breast Cancer and implications for clinical practice.  Biochim    Biophys Acta. 2017 Dec;1868(2):527-537.
  • Méndez-Pertuz M, Martínez P, Blanco-Aparicio C, Gómez-Casero E, Belen García A, Martínez-Torrecuadrada J, Palafox M, Cortés J, Serra V, Pastor J, Blasco MA. Modulation of telomere protection by the PI3K/AKT pathway. Nat Commun. 2017 Nov 2;8(1):1278.
  • Kim SB, Dent R, Im SA, Espié M, Blau S, Tan AR, Isakoff SJ, Oliveira M, Saura C, Wongchenko MJ, Kapp AV, Chan WY, Singel SM, Maslyar DJ, Baselga J; LOTUS investigators. Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.Lancet Oncol. 2017 Oct;18(10):1360-1372.
  • Rugo HS, Trédan O, Ro J, Morales SM, Campone M, Musolino A, Afonso N, Ferreira M, Park KH, Cortes J, Tan AR, Blum JL, Eaton L, Gause CK, Wang Z, Im E, Mauro DJ, Jones MB, Denker A, Baselga J. A randomized phase II trial of ridaforolimus, dalotuzumab, and exemestane compared with ridaforolimus and exemestane in patients with advanced breast cancer.Breast Cancer Res Treat. 2017 Oct;165(3):601-609.
  • Pérez-Alea M, McGrail K, Sánchez-Redondo S, Ferrer B, Fournet G, Cortés J, Muñoz E, Hernandez-Losa J, Tenbaum S, Martin G, Costello R, Ceylan I, Garcia-Patos V, Recio JA. ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment. 2017 Oct 12;36(41):5695-5708.
  • Dickler MN, Tolaney SM, Rugo HS, Cortés J, Diéras V, Patt D, Wildiers H, Hudis CA, O’Shaughnessy J, Zamora E, Yardley DA, Frenzel M, Koustenis A, Baselga J. MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR+/HER2- Metastatic Breast Cancer.Clin Cancer Res. 2017 Sep 1;23(17):5218-5224.
  • Vega JF, Ramos J, Cruz VL, Vicente-Alique E, Sánchez-Sánchez E, Sánchez-Fernández A, Wang Y, Hu P, Cortés J, Martínez-Salazar J. Molecular and hydrodynamic properties of human epidermal growth factor receptor HER2 extracellular domain and its homodimer: Experiments and multi-scale simulations.Biochim Biophys Acta. 2017 Sep;1861(9):2406-2416.
  • Saha P, Regan MM, Pagani O, Francis PA, Walley BA, Ribi K, Bernhard J, Luo W, Gómez HL, Burstein HJ, Parmar V, Torres R, Stewart J, Bellet M, Perelló A, Dane F, Moreira A, Vorobiof D, Nottage M, Price KN, Coates AS, Goldhirsch A, Gelber RD, Colleoni M, Fleming GF; SOFT; TEXT Investigators; International Breast Cancer Study Group. Treatment Efficacy, Adherence, and Quality of Life Among Women Younger Than 35 Years in the International Breast Cancer Study Group TEXT and SOFT Adjuvant Endocrine Therapy Trials.J Clin Oncol. 2017 Sep 20;35(27):3113-3122
  • Cortés J, Rugo HS, Awada A, Twelves C, Perez EA, Im SA, Gómez-Pardo P, Schwartzberg LS, Diéras V, Yardley DA, Potter DA, Mailliez A, Moreno-Aspitia A, Ahn JS, Zhao C, Hoch U, Tagliaferri M, Hannah AL, O’Shaughnessy J. Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial. Breast Cancer Res Treat. 2017 Sep;165(2):329-341
  • Mancebo G, Sole-Sedeno JM, Pino O, Miralpeix E, Mojal S, Garrigos L,Lloveras B, Navarro P, Gibert J, Lorenzo M, Aran I, Carreras R, Alameda F. Prognostic impact of CD133 expression in Endometrial Cancer Patients.Sci Rep. 2017 Aug 9;7(1):7687.
  • Muñoz-Couselo E, Adelantado EZ, Ortiz C, García JS, Perez-Garcia J. NRAS-mutant melanoma: current challenges and future prospect.Onco Targets Ther. 2017 Aug 8;10:3941-3947. Review.
  • Baselga J, Im SA, Iwata H, Cortés J,De Laurentiis M, Jiang Z, Arteaga CL, Jonat W, Clemons M, Ito Y, Awada A, Chia S, Jagiełło-Gruszfeld A, Pistilli B, Tseng LM, Hurvitz S, Masuda N, Takahashi M, Vuylsteke P, Hachemi S, Dharan B, Di Tomaso E, Urban P, Massacesi C, Campone M.Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial.Lancet Oncol. 2017 Jul;18(7):904-916.
  • González-Cao M, Arance A, Piulats JM, Marquez-Rodas I, Manzano JL, Berrocal A, Crespo G, Rodriguez D, Perez-Ruiz E, Berciano M, Soria A, Castano AG, Espinosa E, Montagut C, Alonso L, Puertolas T, Aguado C, Royo MA, Blanco R, Rodríguez JF, Muñoz E, Mut P, Barron F, Martin-Algarra S; Spanish Melanoma Group. Pembrolizumab for advanced melanoma: experience from the Spanish Expanded Access Program. Clin Transl Oncol. 2017 Jun;19(6):761-768
  • Baselga J, Morales SM, Awada A, Blum JL, Tan AR, Ewertz M, Cortes J, Moy B, Ruddy KJ, Haddad T, Ciruelos EM, Vuylsteke P, Ebbinghaus S, Im E, Eaton L, Pathiraja K, Gause C, Mauro D, Jones MB, Rugo HS. A phase II study of combined ridaforolimus and dalotuzumab compared with exemestane in patients with estrogen receptor-positive breast cancer.Breast Cancer Res 2017 Jun;163(3):535-544
  • Peg V, Sansano I, Vieites B, Bernet L, Cano R, Córdoba A, Sancho M, Martín MD, Vilardell F, Cazorla A, Espinosa-Bravo M, Pérez-García JM, Cortés J, Rubio IT, Ramón Y Cajal S. Role of total tumour load of sentinel lymph node on survival in early breast cancer patients. 2017 Jun;33:8-13
  • Maetens M, Brown D, Irrthum A, Aftimos P, Viale G, Loibl S, Laes JF, Campbell PJ, Thompson A, Cortes J, Seiler S, Vinnicombe S, Oliveira M, Rothé F, Bareche Y, Fumagalli D, Zardavas D, Desmedt C, Piccart M, Loi S, Sotiriou C. The AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group.NPJ Breast Cancer. 2017 Jun 29;3:23.
  • Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EEW, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JWM, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA. Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. 2017 May 11;36(19):2737-2749.
  • Twelves C, Cortés J, O’Shaughnessy J, Awada A, Perez EA, Im SA, Gómez-Pardo P, Schwartzberg LS, Diéras V, Yardley DA, Potter DA, Mailliez A, Moreno-Aspitia A, Ahn JS, Zhao C, Hoch U, Tagliaferri M, Hannah AL, Rugo HS. Health-related quality of life in patients with locally recurrent or metastatic breast cancer treated with etirinotecan pegol versus treatment of physician’s choice: Results from the randomised phase III BEACON trial.Eur J Cancer. 2017 May;76:205-215.
  • Llombart-Cussac A, Cortés J, Paré L, Galván P, Bermejo B, Martínez N, Vidal M, Pernas S, López R, Muñoz M, Nuciforo P, Morales S, Oliveira M, de la Peña L, Peláez A, Prat A. HER2-enriched subtype as a predictor of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer (PAMELA): an open-label, single-group, multicentre, phase 2 trial.Lancet Oncol. 2017 Apr;18(4):545-554
  • Swain SM, Schneeweiss A, Gianni L, Gao JJ, Stein A, Waldron-Lynch M, Heeson S, Beattie MS, Yoo B, Cortes J, Baselga J. Incidence and management of diarrhea in patients with HER2-positive breast cancer treated with pertuzumab.Ann Oncol. 2017 Apr 1;28(4):761-768
  • Quintela-Fandino M, Soberon N, Lluch A, Manso L, Calvo I, Cortes J, Moreno-Antón F, Gil-Gil M, Martinez-Jánez N, Gonzalez-Martin A, Adrover E, de Andres R, Viñas G, Llombart-Cussac A, Alba E, Mouron S, Guerra J, Bermejo B, Zamora E, García-Saenz JA, Simon SP, Carrasco E, Escudero MJ, Campo R, Colomer R, Blasco MA. Critically short telomeres and toxicity of chemotherapy in early breast cancer. 2017 Mar 28;8(13):21472-21482.
  • Quintela-Fandino M, Lluch A, Manso L, Calvo I, Cortes J, García-Saenz JA, Gil-Gil M, Martinez-Jánez N, Gonzalez-Martin A, Adrover E, de Andres R, Viñas G, Llombart-Cussac A, Alba E, Guerra J, Bermejo B, Zamora E, Moreno-Anton F, Pernas Simon S, Carrato A, Lopez-Alonso A, Escudero MJ, Campo R, Carrasco E, Palacios J, Mulero F, Colomer R. 18F-fluoromisonidazole PET and Activity of Neoadjuvant Nintedanib in Early HER2-Negative Breast Cancer: A Window-of-Opportunity Randomized Trial.Clin Cancer Res. 2017 Mar 15;23(6):1432-1441
  • Hierro C, Azaro A, Argilés G, Elez E, Gómez P, Carles J, Rodon J. Unveiling changes in the landscape of patient populations in cancer early drug development. Oncotarget. 2017 Feb 21;8(8):14158-14172.
  • Cardoso F, Harbeck N, Barrios CH, Bergh J, Cortés J,El Saghir N, Francis PA, Hudis CA, Ohno S, Partridge AH, Sledge GW, Smith IE, Gelmon KA. Research needs in breast cancer.Ann Oncol. 2017 Feb 1;28(2):208-217
  • Sharma P, López-Tarruella S, García-Saenz JA, Ward C, Connor CS, Gómez HL, Prat A, Moreno F, Jerez-Gilarranz Y, Barnadas A, Picornell AC, Del Monte-Millán M, Gonzalez-Rivera M, Massarrah T, Pelaez-Lorenzo B, Palomero MI, González Del Val R, Cortes J,Fuentes Rivera H, Bretel Morales D, Márquez-Rodas I, Perou CM, Wagner JL, Mammen JM, McGinness MK, Klemp JR, Amin AL, Fabian CJ, Heldstab J, Godwin AK, Jensen RA, Kimler BF, Khan QJ, Martin M. Efficacy of Neoadjuvant Carboplatin plus Docetaxel in Triple-Negative Breast Cancer: Combined Analysis of Two Cohorts.Clin Cancer Res. 2017 Feb 1;23(3):649-65
  • Musolino A, Campone M, Neven P, Denduluri N, Barrios CH, Cortes J, Blackwell K, Soliman H, Kahan Z, Bonnefoi H, Squires M, Zhang Y, Deudon S, Shi MM, André F. Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2- breast cancer that had progressed during or after prior endocrine therapy.Breast Cancer Res. 2017 Feb 10;19(1):1
  • Saura C, Roda D, Roselló S, Oliveira M, Macarulla T, Pérez-Fidalgo JA, Morales-Barrera R, Sanchis-García JM, Musib L, Budha N, Zhu J, Nannini M, Chan WY, Sanabria Bohórquez SM, Meng RD, Lin K, Yan Y, Patel P, Baselga J, Tabernero J, Cervantes A. A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors.Cancer Discov. 2017 Jan;7(1):102-113.
  • Bruna A, Rueda OM, Greenwood W, Batra AS, Callari M, Batra RN, Pogrebniak K, Sandoval J, Cassidy JW, Tufegdzic-Vidakovic A, Sammut SJ, Jones L, Provenzano E, Baird R, Eirew P, Hadfield J, Eldridge M, McLaren-Douglas A, Barthorpe A, Lightfoot H, O’Connor MJ, Gray J, Cortes J, Baselga J, Marangoni E, Welm AL, Aparicio S, Serra V, Garnett MJ, Caldas C. A Biobank of Breast Cancer Explants with Preserved Intra tumor Heterogeneity to Screen AnticancerCompounds. Cell. 2016 Sep 22;167(1):260-274.e22.
  • Hadji P, Coleman RE, Wilson C, Powles TJ, Clézardin P, Aapro M, Costa L, Body JJ, Markopoulos C, Santini D, Diel I, Di Leo A, Cameron D, Dodwell D, Smith I, Gnant M, Gray R, Harbeck N, Thurlimann B, Untch M, Cortes J, Martin M, Albert US, Conte PF, Ejlertsen B, Bergh J, Kaufmann M, Holen I. Adjuvant bisphosphonates in early breast cancer: consensus guidance for clinical practice from a European Panel. Ann Oncol. 2016 Mar;27(3):379-90.
  • Phillips KA, Regan MM, Ribi K, Francis PA, Puglisi F, Bellet M, Spazzapan S, Karlsson P, Budman DR, Zaman K, Abdi EA, Domchek SM, Feng Y, Price KN, Coates AS, Gelber RD, Maruff P, Boyle F, Forbes JF, Ahles T, Fleming GF, Bernhard J. Adjuvant ovarian function suppression and cognitive function in women with breast cancer. Br J Cancer. 2016 Apr 26;114(9):956-64.
  • Ribi K, Luo W, Bernhard J, Francis PA, Burstein HJ, Ciruelos E, Bellet M, Pavesi L, Lluch A, Visini M, Parmar V, Tondini C, Kerbrat P, Perelló A, Neven P, Torres R, Lombardi D, Puglisi F, Karlsson P, Ruhstaller T, Colleoni M, Coates AS, Goldhirsch A, Price KN, Gelber RD, Regan MM, Fleming GF. Adjuvant Tamoxifen Plus Ovarian Function Suppression Versus Tamoxifen Alone in PremenopausalWomen With Early Breast Cancer: Patient-Reported Outcomes in the Suppression of Ovarian FunctionTrial. J Clin Oncol. 2016 May 10;34(14):1601-10.
  • Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Sarosiek KA, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D’Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI. CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. Cell Rep. 2016 Nov 22;17(9):2367-2381.
  • Liu MC, Cortés J, O’Shaughnessy J. Challenges in the treatment of hormone receptor-positive, HER2-negative metastatic breast cancer with brain metastases. Cancer Metastasis Rev. 2016 Jun;35(2):323-32.
  • Diaz-Botero S, Espinosa-Bravo M, Gonçalves VR, Esgueva-Colmenarejo A, Peg V, Perez J, Cortes J, Rubio IT. Different Prognostic Implications of Residual Disease After Neoadjuvant Treatment: Impact of Ki 67 and Site of Response. Ann Surg Oncol. 2016 Nov;23(12):3831-3837.
  • Herrera-Abreu MT, Palafox M, Asghar U, Rivas MA, Cutts RJ, Garcia-Murillas I, Pearson A, Guzman M, Rodriguez O, Grueso J, Bellet M, Cortés J, Elliott R, Pancholi S, Baselga J, Dowsett M, Martin LA, Turner NC, Serra V. Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer. Cancer Res. 2016 Apr 15;76(8):2301-13.
  • López-Miranda E, Cortés J. Etirinotecan pegol for the treatment of breast cancer. Expert Opin Pharmacother. 2016;17(5):727-34.
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