RADIATION ONCOLOGY GROUP

CLINICAL RESEARCH
Radiation Oncology Group

JORDI GIRALT
Principal Investigator
Biosketch

VHIO’s Radiation Oncology Group is integrated within the Radiation Oncology Department of the Vall d’Hebron University Hospital (HUVH), and is actively involved in the multidisciplinary treatment of patients with malignant tumors. We also participate either as Principal Investigators or research collaborators in a number of pioneering clinical trials, translational research projects, as well as technology development programs.

In 2019 we have renewed three linacs thanks to a donation received from the Amancio Ortega Foundation. The machines incorporate all the very latest technology and the implementation of these highly complex techniques requires additional expertise from our service, special trainings in order to establish the indications, administration procedures, quality control methods, as well as the implementation of the necessary tools for the measurement of results. These include:

  • Breathing control for the treatment of tumors that are located in moving body regions such as the lungs and liver. Therapy is synchronized with respiratory rhythm. This technique is especially indicated in stereotactic body radiotherapy (SBRT).
  • Deep inspiration breath hold (DIBH) is a radiation therapy technique where patients take a deep breath during treatment. The patient is asked to take a deep breath and hold this breath while the radiation is delivered. Deep breathing ensures that the heart moves away from the chest and thus receives a lower dose.
  • Real-Time Tumor-Tracking Radiotherapy is used in the hypofractionated treatment of prostate cancer. Markers are placed on the prostate and during therapy the system recognizes them. If the prostate moves (e.g. bladder or rectum), the technique can detect this and indicates the correction.
  • Adaptive radiotherapy is used for the treatment of gynecological and bladder tumors, which move and can change position. A three-dimensional image is taken before therapy is administered and indicates where the organ requires therapy, with a treatment plan that best adapts to the position of the organ at that precise moment.
  • Radiosurgery of small lesions is applied for the treatment of small brain tumors and/or metastases, and for some non-oncological conditions such as trigeminal neuralgia that no longer responds to standard therapy, and some Parkinsonism conditions. A very high dose is administered in very small volume (5-10 mm in diameter), requiring extremely precise techniques.

STRATEGIC GOALS

  • Technology development: acquisition of new equipment to implement cutting edge clinical techniques such as rotational radiotherapy – with intensity modulated arc therapy (VMAT), adaptive radiotherapy, respiratory control radiotherapy (RT4D), and image-guided radiotherapy (IGRT).
  • Translational research: application of insights into cancer biology as well as healthy tissue in order to personalize therapy matched to the characteristics and specificities of each patient, each individual tumor.
  • Continue to obtain the ISO 9001/2008 recertification in the field of radiation oncology.
  • Clinical research. To accelerate and advance clinical research into combined radio-immunotherapy therapy.

 


HIGHLIGHTS

  • Over 90% of our patients treated with radical radiotherapy have received highly complex techniques.
  • We now started therapy using our Halcyon linac – the first ever to be installed in Spain.
  • Our group has initiated a project for combined radiotherapy and nanoparticles in head and neck cancer.
  • We have implemented the `breath hold’ technique, with the first of our patients having already received this treatment approach.
  • We participate as national heads of radiotherapy quality control procedures in the International Society of Paediatric Oncology (SIOP) trials for medulloblastoma (PNET5), ependymoma (EP2), and Wilms (umbrella).

 


TEAM

  • Principal Investigator
    • Jordi Giralt
  • Radiation Oncologists
    • Manel Altabas
    • Sergi Benavente
    • Alexandra Giraldo
    • Raquel Granado
    • Beatriz Gutierrez
    • Begoña Navalpotro
    • Maria Magdalena Marti
    • Xavier Maldonado
    • Soraya Mico
    • Mónica Ramos
    • Victoria Reyes

 


Most relevant scientific publications

  • Verges R, Giraldo A, Seoane A, Toral E, Ruiz MC, Pons A, Giralt J. Does ITV vaginal procedure ensure dosimetric coverage during IMRT of post-operative gynaecological tumours without instructions concerning rectal filling? Rep Pract Oncol Radiother. 2018 Mar-Apr;23(2):136-142.
  • Morote J, Comas I, Planas J, Maldonado X, Celma A, Placer J, Ferrer R, Carles J, Regis L. Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy. Clin Genitourin Cancer. 2018 Apr;16(2):e491-e496.
  • Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO; SIOPE BTG Radiotherapy Group. SIOPE – Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy. Radiother Oncol. 2018 Aug;128(2):192-197.
  • Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche’ F, Nicolai P, O’Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2018 Jan;126(1):3-24.
  • Rueda A, Giralt J, Mañós M, Lozano A, Sistiaga A, García-Miragall E, Cacicedo J, Esteban F, Scola B, Contreras J, Ruiz A, Carral A, Sanchez-Aniceto G, Pastor M, Herranz JJ, Bernal M, Mesía R. Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 2). Oral Oncol. 2017 Jul;70:65-72. doi: 10.1016/j.oraloncology.2017.04.005.
  • Mañós M, Giralt J, Rueda A, Cabrera J, Martinez-Trufero J, Marruecos J, Lopez-Pousa A, Rodrigo JP, Castelo B, Martínez-Galán J, Arias F, Chaves M, Herranz JJ, Arrazubi V, Baste N, Castro A, Mesía R. Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 1). Oral Oncol. 2017 Jul;70:58-64. doi: 10.1016/j.oraloncology.2017.04.004.
  • Alsina M, Rivera F, Ramos FJ, Galán M, López R, García-Alfonso P, Alés-Martinez JE, Queralt B, Antón A, Carrato A, Grávalos C, Méndez-Vidal MJ, López C, de Mena IR, Tabernero J, Giralt J, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and Grupo de Investigación Clínica en Oncología Radioterápica (GICOR). Correction to: A Phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients. Target Oncol. 2017 Dec 14. doi: 10.1007/s11523-017-0544-z.
  • Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche’ F, Nicolai P, O’Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol. 2017 Nov 24. pii: S0167-8140(17)32656-7. doi: 10.1016/j.radonc.2017.10.016.
  • Morote J, Comas I, Planas J, Maldonado X, Celma A, Placer J, Ferrer R, Carles J, Regis L. Serum Testosterone Levels in Prostate Cancer Patients Undergoing Luteinizing Hormone-Releasing Hormone Agonist Therapy. Clin Genitourin Cancer. 2017 Nov 30. pii: S1558-7673(17)30341-5. doi: 10.1016/j.clgc.2017.10.025.
  • Casas F, Henríquez I, Bejar A, Maldonado X, Alvarez A, González-Sansegundo C, Boladeras A, Ferrer F, Hervás A, Herruzo I, Caro M, Rodriguez I, Ferrer C. Intermittent versus continuous androgen deprivation therapy to biochemical recurrence after external beam radiotherapy: a phase 3 GICOR study. Clin Transl Oncol. 2017 Mar;19(3):373-378. doi: 10.1007/s12094-016-1538-5.
  • Martínez-Garcia M, Álvarez-Linera J, Carrato C, Ley L, Luque R, Maldonado X, Martínez-Aguillo M, Navarro LM, Vaz-Salgado MA, Gil-Gil M. SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017). Clin Transl Oncol. 2017 Oct 30. doi:10.1007/s12094-017-1763-6.
  • Toledo M, Sarria-Estrada S, Quintana M, Maldonado X, Martinez-Ricarte F, Rodon J, Auger C, Aizpurua M, Salas-Puig J, Santamarina E, Martinez-Saez E. Epileptic features and survival in glioblastomas presenting with seizures. Epilepsy Res. 2017 Feb;130:1-6.doi:10.1016/j.eplepsyres.2016.12.013.
  • Giraldo A, Benavente S, Ramos M, Vergés R, Coronil O, Arbeláez L, Maldonado X, Altabas M, Mollà M, Reyes V, Navalpotro B, Giralt J. Effectiveness of radiotherapy for metastatic spinal cord compression in patients with short life expectancy. Rep Pract Oncol Radiother. 2017 Jan-Feb;22(1):58-63.
  • Regis L, Planas J, Carles J, Maldonado X, Comas I, Ferrer R, Morote J. Free Testosterone During Androgen Deprivation Therapy Predicts Castration-Resistant Progression Better Than Total Testosterone. 2017 Jan;77(1):114-120. doi: 10.1002/pros.23256.
  • Alsina M, Rivera F, Ramos FJ, Galán M, López R, García-Alfonso P, Alés-Martinez JE, Queralt B, Antón A, Carrato A, Grávalos C, Méndez-Vidal MJ, López C, de Mena IR, Tabernero J, Giralt J, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and Grupo de Investigación Clínica en Oncología Radioterápica (GICOR). A phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients. Target Oncol. 2017 Nov 11. doi: 10.1007/s11523-017-0536-z.
  • Cambra MJ, Farrús B, Moreno F, Anglada L, Arenas M, Ballester R, Casals J, Cusidó M, García V, Gutiérrez C, Mollà M, Pedro A, Reyes V, Sanz X. Management of breast ductal carcinoma in situ in Catalonia, Spain: Results from the Grup Oncologic Calalà-Occità-Catalonia survey with 9-year follow up. Breast. 2017 Oct;35:196-202. doi: 10.1016/j.breast.2017.08.002.
  • Christiaens M, Collette S, Overgaard J, Gregoire V, Kazmierska J, Castadot P, Giralt J, Grant W, Tomsej M, Bar-Deroma R, Monti AF, Hurkmans CW, Weber DC. Quality assurance of radiotherapy in the ongoing EORTC 1219-DAHANCA-29 trial for HPV/p16 negative squamous cell carcinoma of the head and neck: Results of the benchmark case procedure. Radiother Oncol. 2017 Jun;123(3):424-430. doi: 10.1016/j.radonc.2017.04.019.
  • Prades J, Algara M, Espinàs JA, Farrús B, Arenas M, Reyes V, García-Reglero V, Cambra MJ, Rubio E, Anglada L, Eraso A, Pedro A, Fuentes-Raspall MJ, Tuset V, Solà J, Borras JM. Understanding variations in the use of hypofractionated radiotherapy and its specific indications for breast cancer: A mixed-methods study. Radiother Oncol. 2017 Apr;123(1):22-28. doi: 10.1016/j.radonc.2017.01.014.
  • Janssens GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K, Benghiat H, Hoeben B, Morales La Madrid A, Kortmann RD, Hargrave D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG, Massimino M, Sturm D, Peters M, Kramm CM. Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group. Eur J Cancer. 2017 Mar;73:38-47. doi: 10.1016/j.ejca.2016.12.007.
  • Gutiérrez Santamaría J, Masiá Gridilla J, Pamias Romero J, Giralt López-de-Sagredo J, Bescós Atín MS. Fat grafting is a feasible technique for the sequelae of head and neck cancer treatment. J Craniomaxillofac Surg. 2017 Jan;45(1):93-98. doi: 10.1016/j.jcms.2016.10.019.
  • Bonner JA, Mesia R, Giralt J, Psyrri A, Keilholz U, Rosenthal DI, Beier F, Schulten J, Vermorken JB.p16, HPV, and Cetuximab: What Is the Evidence? Oncologist. 2017 Jul;22(7):811-822. doi: 10.1634/theoncologist.2016-0433.
  • Barrera-Ochoa S, Gallardo-Calero I, Sallent A, López-Fernández A, Vergés R, Giralt J, Aguirre-Canyadell M, Velez R. New and safe experimental model of radiation-induced neurovascular histological changes for microsurgical research. Lab Anim. 2017 Apr;51(2):124-137. doi: 10.1177/0023677216656221. Epub 2016 Jul 9.
  • Bonner JA, Giralt J, Harari PM, Baselga J, Spencer S, Bell D, Raben D, Liu J, Schulten J, Ang KK, Rosenthal DI. Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: Assessment from a phase 3 registration trial. Eur J Cancer. 2016 Sep;64:1-11.
  • Zapatero, A, Guerrero A, Maldonado X, Alvarez A, Gonzàlez Sansegundo C, Cabeza MA, Macias V, Olivé P, Casas F, Boladeras A, Martin de Vidales C, Vázquez de la Torre M, Calvo F Late Radiation and cardiovascular adverse effects following androgen deprivation and high dose radiotherapy in prostate cáncer: Results fron DART 01/05 Randomized Phase III trial. Int J Radiation Oncol Biol Phys, 2016 Vol. 96, Issue 2, 341–348.
  • Bonner J, Giralt J, Harari P, Spencer S, Schulten J, Hossain A, Chang SC, Chin S, Baselga J. Cetuximab and Radiotherapy in Laryngeal Preservation for Cancers of the Larynx and Hypopharynx: A Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2016 Sep 1;142(9):842-9.
  • Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CM, Burnet NG, Elliott R, Coles C, Hall E, Fachal L, Vega A, Gómez-Caamaño A, Talbot CJ, Symonds RP, De Ruyck K, Thierens H, Ost P, Chang-Claude J, Seibold P, Popanda O, Overgaard M, Dearnaley D, Sydes MR, Azria D, Koch CA, Parliament M, Blackshaw M, Sia M, Fuentes-Raspall MJ, Ramon Y Cajal T, Barnadas A, Vesprini D, Gutiérrez-Enríquez S, Mollà M, Díez O, Yarnold JR, Overgaard J, Bentzen SM, Alsner J. International Radiogenomics Consortium (RgC). Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. Radiother Oncol. 2016 Dec;121(3):431-439.
  • Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesía R, Zhang A, Oliner KS, VanderWalde A. Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015;16(2):221-232.
  • Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J. Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015;16(2):208-220.
  • Zapatero A, Guerrero A, Maldonado X, Alvarez A, Gonzalez San Segundo C, Cabeza Rodríguez MA, Macias V, Pedro Olive A, Casas F, Boladeras A, de Vidales CM, Vazquez de la Torre ML, Villà S, Perez de la Haza A, Calvo FA. High-dose radiotherapy with short-term or long-term androgen deprivation in localized prostate cancer (DART01/05 GICOR): a randomised, controlled, phase 3 trial. Lancet Oncol. 2015;16(3):320-327.
  • Rosenthal DI, Harari PM, Giralt J, Bell D, Raben D, Liu J, Schulten J, Ang KK, Bonner JA. Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab. J. Clin. Oncol. 2016 Apr; 34(12): 1300-8
  • Mesia R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J. Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015 Feb; 16(2): 208-20
  • Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesia R, Zhang A, Oliner KS, VanderWalde A.  Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015 Feb; 16(2): 221-32
  • Bosset JF, Calais G, Mineur L, Maingon P, Stojanovic-Rundic S, Bensadoun RJ, Bardet E, Beny A, Ollier JC, Bolla M, Marchal D, Van Laethem JL, Klein V, Giralt J, Clavère P, Glanzmann C, Cellier P, Collette L.  Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study. Lancet Oncol. 2014 Feb; 15(2): 184-90
  • Sclafani F, González D, Cunningham D, Hulkki Wilson S, Peckitt C, Giralt J, Glimelius B, Roselló Keränen S, Wotherspoon A, Brown G, Tait D, Oates J, Chau I.  RAS mutations and cetuximab in locally advanced rectal cancer: results of the EXPERT-C trial. Eur. J. Cancer 2014 May; 50(8): 1430-6
  • Angelini PD, Zacarias Fluck MF, Pedersen K, Parra-Palau JL, Guiu M, Bernadó Morales C, Vicario R, Luque-García A, Navalpotro NP, Giralt J, Canals F, Gomis RR, Tabernero J, Baselga J, Villanueva J, Arribas J.  Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence. Cancer Res. 2013 Jan; 73(1): 450-8
  • Heukelom J, Hamming O, Bartelink H, Hoebers F, Giralt J, Herlestam T, Verheij M, van den Brekel M, Vogel W, Slevin N, Deutsch E, Sonke JJ, Lambin P, Rasch C.  Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer.BMC Cancer 2013; 13: 84
  • Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, Navajas A, Massimino M, Reddingius R, Benesch M, Carrie C, Taylor R, Gandola L, Björk-Eriksson T, Giralt J, Oldenburger F, Pietsch T, Figarella-Branger D, Robson K, Forni M, Clifford SC, Warmuth-Metz M, von Hoff K, Faldum A, Mosseri V, Kortmann R.  Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial. J. Clin. Oncol. 2012 Sep; 30(26): 3187-93
  • Beltran M, Ramos M, Rovira JJ, Perez-Hoyos S, Sancho M, Puertas E, Benavente S, Ginjaume M, Giralt J.  Dose variations in tumor volumes and organs at risk during IMRT for head-and-neck cancer. J Appl Clin Med Phys 2012; 13(6): 3723

All publications

  • Giralt J, Tao Y, Kortmann RD, Zasadny X, Contreras-Martinez J, Ceruse P, Arias de la Vega F, Lalla RV, Ozsahin EM, Pajkos G, Mazar A, Attali P, Bossi P, Vasseur B, Sonis S, Henke M, Bensadoun RJ. Randomized Phase 2 Trial of a Novel Clonidine Mucoadhesive Buccal Tablet for the Amelioration of Oral Mucositis in Patients Treated With Concomitant Chemoradiation Therapy for Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2019 Oct 25. pii: S0360-3016(19)33905-7. doi: 10.1016/j.ijrobp.2019.10.023.
  • de Rojas T, Clementel E, Giralt J, Cruz O, Boterberg T, Kortmann RD, Gaze MN, Moreno L, Janssens GO; SIOP-Europe QUARTET Project and of the EORTC. Radiotherapy practice for paediatric brain tumors across Europe and quality assurance initiatives: Current situation, international survey and future perspectives.Eur J Cancer. 2019 Jun;114:36-46. doi: 10.1016/j.ejca. 2019.03.018. Epub 2019 Apr 28.
  • Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O’Sullivan B, Bourhis J, Grégoire V. Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update.Radiother Oncol. 2019 May;134:1-9. doi: 10.1016/j.radonc.2019.01.018. Epub 2019 Jan 30.
  • Rodríguez A, Arenas M, Lara PC, López-Torrecilla J, Algara M, Conde A, Pérez-Montero H, Muñoz JL, Peleteiro P, Pérez-Calatayud MJ, Contreras J, Ferrer C; Spanish Society of Oncology and Radiotherapy (SEOR) Analysis Group. Are there enough radiation oncologists to lead the new Spanish radiotherapy?Clin Transl Oncol. 2019 Apr 3. doi: 10.1007/s12094-019-02095-x.
  • Seibold P, Webb A, Aguado-Barrera ME, Azria D, Bourgier C, Brengues M, Briers E, Bultijnck R, Calvo-Crespo P, Carballo A, Choudhury A, Cicchetti A, Claßen J, Delmastro E, Dunning AM, Elliott RM, Fachal L, Farcy-Jacquet MP, Gabriele P, Garibaldi E, Gómez-Caamaño A, Gutiérrez-Enríquez S, Higginson DS, Johnson K, Lobato-Busto R, Mollà M, Müller A, Payne D, Peleteiro P, Post G, Rancati T, Rattay T, Reyes V, Rosenstein BS, De Ruysscher D, De Santis MC, Schäfer J, Schnabel T, Sperk E, Symonds RP, Stobart H, Taboada-Valladares B, Talbot CJ, Valdagni R, Vega A, Veldeman L, Ward T, Weißenberger C, West CML, Chang-Claude J; REQUITE consortium.REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapyfor breast, lung or prostate cancer.Radiother Oncol. 2019 Sep;138:59-67.
  • Cambra MJ, Moreno F, Sanz X, Anglada L, Mollà M, Reyes V, Arenas M, Pedro A, Ballester R, García V, Casals J, Cusidó M, Jimenez C, Escribà JM, Macià M, Solé JM, Arcusa A, Seguí MA, Gonzalez S, Farrús B, Biete A. Role of boost radiotherapy for local control of pure ductal carcinoma in situ after breast-conserving surgery: a multicenter, retrospective study of 622 patients.Clin Transl Oncol. 2019 Jul 1.
  • Bellet M, Ahmad F, Villanueva R, Valdivia C, Palomino-Doza J, Ruiz A, Gonzàlez X, Adrover E, Azaro A, Valls-Margarit M, Parra JL, Aguilar J, Vidal M, Martín A, Gavilá J, Escrivá-de-Romaní S, Perelló A, Hernando C, Lahuerta A, Zamora P, Reyes V, Alcalde M, Masanas H, Céliz P, Ruíz I, Gil M, Seguí MÀ, de la Peña L. Palbociclib and ribociclib in breastcancer: consensus workshop on the management of concomitant medication.Ther Adv Med Oncol. 2019 May 10.
  • Garcia-Mayea Y, Mir C, Muñoz L, Benavente S, Castellvi J, Temprana J, Maggio V, Lorente J, Paciucci R, LLeonart ME. Autophagy inhibition as a promising therapeutic target for laryngeal cancer. Carcinogenesis.2019 May 3. pii: bgz080. doi: 10.1093/carcin/bgz080.
  • Guillem V., Algaba F., Arranz JA., Cassinello J., Climent MA., Duran I., Gómez de Liaño A., Maldonado X., Puente J., Rubio J. NCCN Clinical Practice Gudelines in Oncology(NCCN Guidelines). European edition: Spain. Version 2.2019-August 6, 2019.
  • Font A., Luque R., Villa JC., Domenech M., Vázquez S., Gallardo E., Virizuela JA., Beato C., Morales-Barrera R., Gelabert A., Macià S., Puente J., Rubio G., Maldonado X.,Pérez Valderrama B., Pinto A., Fernández Calv o O., Grande E., Garde Noguera J., Fernández Parra E., Arranz Ja. The Challenge of Managing Bladder Cancer and Upper Tract Urothelial Carcinoma: A Review with treatment recommendations from the Spanish Oncology GenitoUrinary Group (SOGUG). Targeted Oncology
  • Carles, E.Gallardo, M.Doménech, A.Font, J.Bellmeunt, M.Fígols, B.Mellado, MI Sáez, C.Suárez, MJ Mémdez, P.Maroto, R.Luque, T.Portugal, R.Aldabó, T.bonfill, R.Morales-Barrera, J.García, S.Macía,X.Maldonado, P.Foro. Phase 2 Randomized Study of Radiation Therapy and 3 Year Androgen Deprivation with or without concurrent weekly Docetaxel in High-Risk localized Prostate Cancer Patients. Int J. Radiat Oncol Biol Phys. 2019 Vol. 103, Issue 2, 344–352.
  • Gil-Moreno A, Carbonell-Socias M, Salicrú S, Bradbury M, García Á, Vergés R, Puig OP, Sánchez-Iglesias JL, Cabrera-Díaz S, de la Torre J, Gómez-Hidalgo NR, Pérez-Benavente A, Díaz-Feijoo B. Nerve-sparing versus non-nerve-sparing radical hysterectomy: surgical and long-term oncological outcomes. Oncotarget. 2019 Jul 16;10(44):4598-4608,
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