CFAH CANCER COMPUTATIONAL BIOLOGY GROUP – VHIO – Vall d'Hebron Institute of Oncology

PRECLINICAL & TRANSLATIONAL RESEARCH
Cancer Computational Biology group

JOSE A. SEOANE
Principal Investigator
Biosketch

The Cancer Computational Biology group leverages epi(genetic) cancer datasets to discover the molecular mechanism involved in cancer initiation, progression, drug resistance and metastasis in order to improve patient outlooks.

Through the group’s work, we have shown how the genes that modify the chromatin structure are associated with chemotherapy resistance in breast cancer (Nature Medicine, 2019). Our goal is to understand how these epigenetic modifications affect drug resistance and how epigenetic drugs can be used to target tumor suppressor genes.

We are also interested in how the machine learning-based integration of multi-omic datasets can aid in the discovery of new cancer subgroups and biomarkers as well as the prediction of outcome and drug response.

We have participated in multiple international consortiums, including The Cancer Genome Atlas, the Human Tumor Atlas Network, Cancer Target Discovery and Development and, most recently, AURORA (metastatic breast cancer multi-omic cohort).


RESEARCH LINES

  • Role of chromatin regulatory elements in drug response and metastasis
  • New epigenetic synthetic lethality-based therapeutic options
  • Patient stratification using multi-omic analysis
  • New epigenetic biomarkers of drug response

STRATEGIC GOALS

  • Understand the role of chromatin regulatory elements in drug response and metastasis
  • Discover new epigenetic biomarkers of drug response
  • Improve therapeutic options by combining epigenetic drugs with other agents

PROJECTS

Targeting synthetic lethality in Chromatin Regulatory Genes for gastrointestinal cancer treatment. Ref PID2020-115097RA-I00. Agencia Estatal de Investigación. 9/2021-8/2025. PI: Jose A. Seoane

Ramon y Cajal Grant. Agencia Estatal de Investigación. 2021-2025.


TEAM

  • Principal Investigator
    • Jose A. Seoane
  • Postdoctoral fellows
    • Silvana Maas
  • Graduate students
    • Jose Linares
  • Master’s degree student
    • Arnau Llinas

PUBLICATIONS

  • DCIS genomic signatures define biology and correlate with clinical outcome: a Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts
    Siri H. Strand, Belén Rivero-Gutiérrez, Kathleen E. Houlahan, Jose A. Seoane, Lorraine King, …,Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R. Marks, Graham A. Colditz, E. Shelley Hwang, Robert B. West
    bioRxiv, June 2021
    10.1101/2021.06.16.448585
  • CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
    Kyuho Han, Sarah E. Pierce, Amy Li, Kaitlyn Spees, Grace R. Anderson, Jose A. Seoane, Yuan-Hung Lo, Michael Dubreuil, Micah Olivas, Roarke A. Kamber, Michael Wainberg, Kaja Kostyrko, Marcus R. Kelly, Maryam Yousefi, Scott W. Simpkins, David Yao, Keonil Lee, Calvin J. Kuo, Peter K. Jackson, Alejandro Sweet-Cordero, Anshul Kundaje, Andrew J. Gentles, Christina Curtis, Monte M. Winslow, Michael C. Bassik
    Nature, 580(7801):136-141, April 2020
    URL: www.nature.com/articles/s41586-020-2099-x
  • Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers
    Nasa Sinnott-Armstrong, Jose A. Seoane, Jonathan K. Pritchard, Christina Curtis, Michael P. Snyder
    bioRxiv, November 2020
    URL:https://www.biorxiv.org/content/10.1101/2020.08.21.239954v1.abstract
  • Chromatin regulators mediate anthracycline sensitivity in breast cancer
    Jose A. Seoane, Jacob G. Kirkland, Jennifer L. Caswell-Jin, Gerald R. Crabtree, Christina Curtis
    Nature Medicine, 25(11):1721-1727, November 2019
    URL: www.nature.com/articles/s41591-019-0638-5
  • Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups
    Oscar M. Rueda, Stephen-John Sammut, Jose A. Seoane, Suet-Feung Chin, Jennifer L. Caswell-Jin, Maurizio Callari, Rajbir Batra, Bernard Pereira, Alejandra Bruna, H. Raza Ali, Elena Provenzano, Bin Liu, Michelle Parisien, Cheryl Gillett, Steven McKinney, Andrew R. Green, Leigh Murphy, Arnie Purushotham, Ian O. Ellis, Paul D. Pharoah, Cristina Rueda, Samuel Aparicio, Carlos Caldas, Christina Curtis
    Nature, 567(7748):399-404, March 2019
    URL: www.nature.com/articles/s41586-019-1007-8
  • Assessment of ERBB2/HER2 status in HER2-equivocal breast cancers by FISH and 2013/2014 ASCO-CAP guidelines
    Michael F. Press, Jose A. Seoane, Christina Curtis, Emmanuel Quinaux, Roberta Guzman, Guido Sauter, Wolfgang Eiermann, John R. Mackey, Nicholas Robert, Tadeusz Pienkowski, John Crown, Miguel Martin, Vicente Valero, Valerie Bee, Yanling Ma, Ivonne Villalobos, Dennis J. Slamon
    JAMA Oncology, 5(3):366-375, March 2019
    URL:jamanetwork.com/journals/jamaoncology/article-abstract/2718266
  • The chromatin accessibility landscape of primary human cancers
    Science, 362(6413), October 2018
    URL: https://science.sciencemag.org/content/362/6413/eaav1898.abstract
  • Canonical correlation analysis for gene-based pleiotropy discovery
    Jose A. Seoane, Colin Campbell, Ian N. M. Day, Juan P. Casas, Tom R. Gaunt
    PLoS Computational Biology, 10(10), October 2014
    URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003876
  • A pathway-based data integration framework for prediction of disease progression
    Jose A. Seoane, Ian N. M. Day, Tom R. Gaunt, Colin Campbell
    Bioinformatics, 30(6):838-845, Mar. 2014
    URL: https://academic.oup.com/bioinformatics/article-abstract/30/6/838/285849