19th Ave New York, NY 95822, USA

Experimental Hematology Group

VHIO’s Experimental Hematology Group conducts translational, pre-clinical and clinical research on hematological neoplasms of both lymphoid and myeloid origin. Our research team is composed of hematologists and biological scientists who work closely together to design, conduct and lead our programs.

We aim to address unmet clinical needs identified by hematologists with the ultimate goal of translating our results to patients by developing early phase clinical trials and defining novel biomarkers to improve diagnosis, prognosis and treatment outcomes.

We seek to provide new therapeutic options for our patients by deciphering the mechanisms implicated in the pathogenesis and progression of hematological malignancies. Our investigators conduct preclinical studies of new therapeutic approaches for patients diagnosed with hematological malignancies. We identify novel biomarkers in hematology that will lead to a more rational and precise diagnosis, prognosis and treatment of patients.

The Hematology Clinical Trials Unit is currently participating in more than 152 recruiting clinical studies, including phase I and basket clinical trials (n=56) and first-in- human studies of targeted therapies, both in lymphoid and myeloid malignancies. Last year 175 patients were included in our clinical studies, with 73 patients enrolled in phase I and basket trials.

Francesc Bosch
Group Leader
Marta-Crespo_pic-setp-2018-(AECC)
Marta Crespo
Senior Researcher
  • We translate preclinical findings into clinical benefit by developing early phase clinical trials and defining new prognostic and predictive factors.
  • Main research lines currently focus on:
    • Deciphering the mechanisms involved in pathogenesis and progression of hematological neoplasms.
    • The preclinical study of new therapeutic regimens in experimental models that mimic the tumoral microenvironment using primary cells, transgenic mice models, PDXs and 3D ex-vivo cultures.
    • Defining new biomarkers for a more rational and precise treatment of patients.
    • Understanding the longitudinal tumor-immune microenvironment crosstalk during the natural history of the disease for personalized and optimal development of immunotherapeutic strategies.
Group Leader
Francesc Bosch
Traslational Research Coordinator
Marta Crespo
Clinical Research Coordinator
Pau Abrisqueta
Experimental Lab Manager
Gemma Pujadas
Hematologists/Lead Investigators
Pere Barba
David Beneitez
David Valcárcel
Hematologists/Lab Specialists
Adoracion Blanco
Sabela Bobillo
Olga Benitez
Cecilia Carpio
Maria Laura Fox
Laura Gallur
Mercedes Gironella
Gloria Hidalgo
Gloria Iacoboni
Moraima Jiménez
Marta Julia
Ana Marin
Maria Fernanda Martinez
Antonieta Molero
Julia Montoro
Mayda Navarrete
Margarita Ortega
Guillem Orti
Ana Ortuño
Carles Palacio
Ana Pérez
Elisa Roldan
Olga Salamero
Silvia Saumell
Barbara Tazon
Moraima Jiménez
Ángel Serna
Lucia Martin
Bárbara Tazón
Post-Doctoral Scientists
Laura Palomo
Iñaki Salvador
Phd Students
Daniel Medina
Cristina Hernandez
Carlota Pages
Patricia Fernández
Soraya Peralta
Technician
Ana María Garrido
Soraya Peralta

Most relevant scientific publications

  • Abrisqueta P, Medina D, Villacampa G, Lu J, Alcoceba M, Carabia J, Boix J, Tazón-Vega B, Iacoboni G, Bobillo S, Marín-Niebla A, González M, Zenz T, Crespo M, Bosch F. A gene expression assay based on chronic lymphocytic leukemia activation in the microenvironment to predict progression. Blood Adv. 2022 Nov 8;6(21):5763-5773.
  • Jiménez M, Roldán E, Fernández-Naval C, Villacampa G, Martinez-Gallo M, Medina-Gil D, Peralta-Garzón S, Pujadas G, Hernández C, Pagès C, Gironella M, Fox L, Orti G, Barba P, Pumarola T, Cabirta A, Catalá E, Valentín M, Marín-Niebla A, Orfao A, González M, Campins M, Ruiz-Camps I, Valcárcel D, Bosch F, Hernández M, Crespo M, Esperalba J, Abrisqueta P. Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies. Blood Adv. 2022 Feb 8;6(3):774-784.
  • Iacoboni G, Rejeski K, Villacampa G, van Doesum JA, Chiappella A, Bonifazi F, Lopez-Corral L, van Aalderen M, Kwon M, Martínez-Cibrian N, Bramanti S, Reguera-Ortega JL, Camacho-Arteaga L, Schmidt C, Marín-Niebla A, Kersten MJ, Martin Garcia-Sancho A, Zinzani PL, Corradini P, van Meerten T, Subklewe M, Barba P. Real-world evidence of brexucabtagene autoleucel for the treatment of relapsed or refractory mantle cell lymphoma. Blood Adv. 2022 Jun 28;6(12):3606-3610.
  • Dickinson MJ, Carlo-Stella C, Morschhauser F, Bachy E, Corradini P, Iacoboni G, Khan C, Wróbel T, Offner F, Trněný M, Wu SJ, Cartron G, Hertzberg M, Sureda A, Perez-Callejo D, Lundberg L, Relf J, Dixon M, Clark E, Humphrey K, Hutchings M. Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma. N Engl J Med. 2022 Dec 15;387(24):2220-2231.
  • Jiménez I, Tazón-Vega B, Abrisqueta P, Nieto JC, Bobillo S, Palacio-García C, Carabia J, Valdés-Mas R, Munuera M, Puigdefàbregas L, Parra G, Esteve-Codina A, Franco-Jarava C, Iacoboni G, Terol MJ, García-Marco JA, Crespo M, Bosch F. Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia. Biomark Res. 2021 May 20;9(1):37.
  • Jiménez M, Roldán E, Fernández-Naval C, Villacampa G, Martinez-Gallo M, Medina-Gil D, Peralta-Garzón S, Pujadas G, Hernández C, Pagès C, Gironella M, Fox L, Orti G, Barba P, Pumarola T, Cabirta A, Catalá E, Valentín M, Marín-Niebla A, Orfao A, González M, Campins M, Ruiz-Camps I, Valcárcel D, Bosch F, Hernández M, Crespo M, Esperalba J, Abrisqueta P. Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies. Blood Adv. 2022 Feb 8;6(3):774-784. Blood Adv. First Edition 29 November 2021 (online prepublication).
  • Tilly H, Morschhauser F, Sehn LH, Friedberg JW, Trněný M, Sharman JP, Herbaux C, Burke JM, Matasar M, Rai S, Izutsu K, Mehta-Shah N, Oberic L, Chauchet A, Jurczak W, Song Y, Greil R, Mykhalska L, Bergua-Burgués JM, Cheung MC, Pinto A, Shin HJ, Hapgood G, Munhoz E, Abrisqueta P, Gau JP, Hirata J, Jiang Y, Yan M, Lee C, Flowers CR, Salles G. Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma. N Engl J Med. Epub 2021 Dec 14.
  • Bishop MR, Dickinson M, Purtill D, Barba P, Santoro A, Hamad N, Kato K, Sureda A, Greil R, Thieblemont C, Morschhauser F, Janz M, Flinn I, Rabitsch W, Kwong YL, Kersten MJ, Minnema MC, Holte H, Chan EHL, Martinez-Lopez J, Müller AMS, Maziarz RT, McGuirk JP, Bachy E, Le Gouill S, Dreyling M, Harigae H, Bond D, Andreadis C, McSweeney P, Kharfan-Dabaja M, Newsome S, Degtyarev E, Awasthi R, Del Corral C, Andreola G, Masood A, Schuster SJ, Jäger U, Borchmann P, Westin JR. Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma. N Engl J Med. Epub 2021 Dec 14.
  • Olga Salamero, Pau Montesinos, Christophe Willekens, José Antonio Pérez-Simón, Arnaud Pigneux, Christian Récher, Rakesh Popat, Cecilia Carpio, César Molinero, Cristina Mascaró, Joaquim Vila, M Isabel Arévalo, Tamara Maes, Carlos Buesa, Francesc Bosch, Tim C P Somervaille. First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia. Journal of Clinical Oncology 2020 Dec 20; 38(36):4260-4273
  • Abrisqueta P, Bosch F. Venetoclax-obinutuzumab: harnessing complexity. Blood 2020 Mar 12; 135(11):788-789
  • Jiménez I, Carabia J, Bobillo S, Palacio C, Abrisqueta P, Pagès C, Nieto JC, Castellví J, Martínez-Ricarte F, Escoda L, Perla C, Céspedes Torrez DH, Boix J, Purroy N, Puigdefàbregas L, Seoane J, Bosch F, Crespo M. Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition. J Neurooncol. 2020 Aug;149(1):13-25.
  • Bobillo S, Crespo M, Escudero L, Mayor R, Raheja P, Carpio C, Rubio-Perez C, Tazón-Vega B, Palacio C, Carabia J, Jiménez I, Nieto JC, Montoro J, Martínez-Ricarte F, Castellvi J, Simó M, Puigdefàbregas L, Abrisqueta P, Bosch F, Seoane, J. Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas. Haematologica. 2020. Epub ahead of print.
  • Carpio C, Bouabdallah R, Ysebaert L, Sancho JM, Salles G, Cordoba R, Pinto A, Gharibo M, Rasco D, Panizo C, Lopez-Martin JA, Santoro A, Salar A, Damian S, Martin A, Verhoef G, Van den Neste E, Wang M, Couto S, Carrancio S, Weng A, Wang X, Schmitz F, WeiX, Hege K, Trotter MWB, Risueño A, Buchholz TJ, Hagner PR, Gandhi AK, Pourdehnad M, Ribrag V. Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier. Blood. 2020 Mar 26;135(13):996-1007.
  • Muntañola A, Villacampa G, Hernández-Rivas JÁ, Alonso R, Mirás F, Osorio S, Baile M, Baltasar P, López Jiménez J, Hernandez-Rodriguez I, Valenciano S, Alfayate A, Gimeno E,Bárez A, Oliveira AC, Riaza R, Romero P, Delgado J, Yáñez L, Zabalza A, Torres A, Gómez-Roncero MI, Crespo M, Córdoba R, Mateos-Mazón JJ, Pérez S, Andreu R, Labrador J, Ruiz ME, Velasquez CA, Terol MJ, Santiago R, Vidal MJ, Campoy García F, Villalón L, Muiña BS, Soler JA, Seri C, Sánchez MJ, Cuesta A, Ramos R, Sánchez- Montalvá A, Ruiz-Camps I, González M, Abrisqueta P, Bosch F; of the GELLC (Grupo Español de Leucemia Linfática Crónica). Clinical characteristics and outcome of SARS-CoV-2 infection in admitted patients with chronic lymphocytic leukemia from a single European country. Exp Hematol Oncol. 2020 Dec 18;9(1):37.
  • Bosch F, Dalla-Favera R. Chronic Lymphocytic Leukaemia: From Genetics to Treatment. Nat Rev Clin Oncol. 16 (11), 684-701, Nov 2019.
  • Bosch F, Cantin G, Cortelezzi A, Knauf W, Tiab M, Turgut M, Zaritskey A, Merot J-L, Tausch E, Trunzer K, Robson S, Gresko E, Böttcher S, Foà R, Stilgenbauer S, Leblond V. Obinutuzumab plus fludarabine and cyclophosphamide in previously untreated, fit patients with chronic lymphocytic leukemia: a subgroup analysis of the GREEN study. Leukemia, 34 (2), 441-450. 2019.
    Flinn IW, Hillmen P, Montillo M, Nagy Z, Illés Á, Etienne G, Delgado J, Kuss BJ, Tam CS, Gasztonyi Z, Offner F, Lunin S, Bosch F, Davids MS, Lamanna N, Jaeger U, Ghia P, Cymbalista F, Portell CA, Skarbnik AP, Cashen AF, Weaver DT, Kelly VM, Turnbull B, Stilgenbauer S. The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL. Blood. 2018 Dec 6;132(23):2446-2455.
  • Stilgenbauer S, Leblond V, Foà R, Böttcher S, Ilhan O, Knauf W, Mikuskova E, Renner C, Tausch E, Woszczyk D, Gresko E, Lundberg L, Moore T, Morris T, Robson S, Bosch F. Obinutuzumab plus bendamustine in previously untreated patients with CLL: a subgroup analysis of the GREEN study. Leukemia. 2018 Aug;32(8):1778-1786.
  • Abrisqueta P, Scott DW, Slack GW, Steidl C, Mottok A, Gascoyne RD, Connors JM, Sehn LH, Savage KJ, Gerrie AS, Villa D. Observation as the initial management strategy in patients with mantle cell lymphoma. Ann Oncol. 2017 Oct 1;28(10):2489-2495.
  • Purroy N, Carabia J, Abrisqueta P, Egia L, Aguiló M, Carpio C, Palacio C, Crespo M, Bosch F. Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signalingin chronic lymphocytic leukemia cells. Oncotarget. 2017 Jan 3;8(1):742-756.
  • Scott DW, Abrisqueta P, Wright GW, Slack GW, Mottok A, Villa D, Jares P, Rauert-Wunderlich H, Royo C, Clot G, Pinyol M, Boyle M, Chan FC, Braziel RM, Chan WC, Weisenburger DD, Cook JR, Greiner TC, Fu K, Ott G, Delabie J, Smeland EB, Holte H, Jaffe ES, Steidl C, Connors JM, Gascoyne RD, Rosenwald A, Staudt LM, Campo E, Rimsza LM; Lymphoma/Leukemia Molecular Profiling Project. New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies. J Clin Oncol. 2017 May 20;35(15):1668-1677.
  • Vitolo U, Trněný M, Belada D, Burke JM, Carella AM, Chua N, Abrisqueta P, Demeter J, Flinn I, Hong X, Kim WS, Pinto A, Shi YK, Tatsumi Y, Oestergaard MZ, Wenger M, Fingerle-Rowson G, Catalani O, Nielsen T, Martelli M, Sehn LH. Obinutuzumab or Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Previously Untreated Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2017 Nov 1;35(31):3529-3537.
  • Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, Marcé BS, López-Guillermo A, Campo E, Monserrat E. ZAP-70 expression as a surrogate for immunoglobulin variable region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764-75.
  • Bosch F, Abrisqueta P, Villamor N, Terol MJ, González-Barca E, Ferra C, González Diaz M, Abella E, Delgado J, Carbonell F, García Marco JA, Escoda L, Ferrer S, Monzó E, González Y, Estany C, Jarque I, Salamero O, Muntañola A, Montserrat E. Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: a new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia. J Clin Oncol. 2009 Sep 20;27(27):4578-84.
  • Montagut C, Dalmases A, Bellosillo B, Crespo M, Pairet S, Iglesias M, Salido M, Gallen M, Marsters S, Tsai SP, Minoche A, Somasekar S, Serrano S, Himmelbauer H, Bellmunt J, Rovira A, Settleman J, Bosch F, Albanell J. Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer. Nat Med. 2012 Jan 22;18(2):221-3
  • Purroy N; Abrisqueta P; Carabia J; Carpio C; Calpe E; Palacio C; Castellví J; Crespo M; Bosch F. Targeting the proliferative and chemoresistant compartment in chronic lymphocytic leukemia by inhibiting survivin protein. Leukemia. 28 – (10), pp. 1993 – 2004.

All publications

  • Abrisqueta P, Medina D, Villacampa G, Lu J, Alcoceba M, Carabia J, Boix J, Tazón-Vega B, Iacoboni G, Bobillo S, Marín-Niebla A, González M, Zenz T, Crespo M, Bosch F. A gene expression assay based on chronic lymphocytic leukemia activation in the microenvironment to predict progression. Blood Adv. 2022 Nov 8;6(21):5763-5773.
  • Jiménez M, Roldán E, Fernández-Naval C, Villacampa G, Martinez-Gallo M, Medina-Gil D, Peralta-Garzón S, Pujadas G, Hernández C, Pagès C, Gironella M, Fox L, Orti G, Barba P, Pumarola T, Cabirta A, Catalá E, Valentín M, Marín-Niebla A, Orfao A, González M, Campins M, Ruiz-Camps I, Valcárcel D, Bosch F, Hernández M, Crespo M, Esperalba J, Abrisqueta P. Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies. Blood Adv. 2022 Feb 8;6(3):774-784.
  • Iacoboni G, Rejeski K, Villacampa G, van Doesum JA, Chiappella A, Bonifazi F, Lopez-Corral L, van Aalderen M, Kwon M, Martínez-Cibrian N, Bramanti S, Reguera-Ortega JL, Camacho-Arteaga L, Schmidt C, Marín-Niebla A, Kersten MJ, Martin Garcia-Sancho A, Zinzani PL, Corradini P, van Meerten T, Subklewe M, Barba P. Real-world evidence of brexucabtagene autoleucel for the treatment of relapsed or refractory mantle cell lymphoma. Blood Adv. 2022 Jun 28;6(12):3606-3610.
  • Dickinson MJ, Carlo-Stella C, Morschhauser F, Bachy E, Corradini P, Iacoboni G, Khan C, Wróbel T, Offner F, Trněný M, Wu SJ, Cartron G, Hertzberg M, Sureda A, Perez-Callejo D, Lundberg L, Relf J, Dixon M, Clark E, Humphrey K, Hutchings M. Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma. N Engl J Med. 2022 Dec 15;387(24):2220-2231.
  • Jiménez I, Tazón-Vega B, Abrisqueta P, Nieto JC, Bobillo S, Palacio-García C, Carabia J, Valdés-Mas R, Munuera M, Puigdefàbregas L, Parra G, Esteve-Codina A, Franco-Jarava C, Iacoboni G, Terol MJ, García-Marco JA, Crespo M, Bosch F. Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia. Biomark Res. 2021 May 20;9(1):37.
  • Jiménez M, Roldán E, Fernández-Naval C, Villacampa G, Martinez-Gallo M, Medina-Gil D, Peralta-Garzón S, Pujadas G, Hernández C, Pagès C, Gironella M, Fox L, Orti G, Barba P, Pumarola T, Cabirta A, Catalá E, Valentín M, Marín-Niebla A, Orfao A, González M, Campins M, Ruiz-Camps I, Valcárcel D, Bosch F, Hernández M, Crespo M, Esperalba J, Abrisqueta P. Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies. Blood Adv. 2022 Feb 8;6(3):774-784. Blood Adv. First Edition 29 November 2021 (online prepublication).
  • Tilly H, Morschhauser F, Sehn LH, Friedberg JW, Trněný M, Sharman JP, Herbaux C, Burke JM, Matasar M, Rai S, Izutsu K, Mehta-Shah N, Oberic L, Chauchet A, Jurczak W, Song Y, Greil R, Mykhalska L, Bergua-Burgués JM, Cheung MC, Pinto A, Shin HJ, Hapgood G, Munhoz E, Abrisqueta P, Gau JP, Hirata J, Jiang Y, Yan M, Lee C, Flowers CR, Salles G. Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma. N Engl J Med. Epub 2021 Dec 14.
  • Bishop MR, Dickinson M, Purtill D, Barba P, Santoro A, Hamad N, Kato K, Sureda A, Greil R, Thieblemont C, Morschhauser F, Janz M, Flinn I, Rabitsch W, Kwong YL, Kersten MJ, Minnema MC, Holte H, Chan EHL, Martinez-Lopez J, Müller AMS, Maziarz RT, McGuirk JP, Bachy E, Le Gouill S, Dreyling M, Harigae H, Bond D, Andreadis C, McSweeney P, Kharfan-Dabaja M, Newsome S, Degtyarev E, Awasthi R, Del Corral C, Andreola G, Masood A, Schuster SJ, Jäger U, Borchmann P, Westin JR. Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma. N Engl J Med. Epub 2021 Dec 14.
  • Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ. Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial. J Clin Oncol. 2021 Jun 20;39(18):1959-1970.
  • Garcia-Manero G, Santini V, Almeida A, Platzbecker U, Jonasova A, Silverman LR, Falantes J, Reda G, Buccisano F, Fenaux P, Buckstein R, Diez Campelo M, Larsen S, Valcarcel D, Vyas P, Giai V, Olíva EN, Shortt J, Niederwieser D, Mittelman M, Fianchi L, La Torre I, Zhong J, Laille E, Lopes de Menezes D, Skikne B, Beach CL, Giagounidis A. Phase III, Randomized, Placebo-Controlled Trial of CC-486 (Oral Azacitidine) in Patients With Lower-Risk Myelodysplastic Syndromes. J Clin Oncol. 2021 May 1;39(13):1426-1436.
  • Pinato DJ, Tabernero J, Bower M, Scotti L, Patel M, Colomba E, Dolly S, Loizidou A, Chester J, Mukherjee U, Zambelli A, Dalla Pria A, Aguilar-Company J, Ottaviani D, Chowdhury A, Merry E, Salazar R, Bertuzzi A, Brunet J, Lambertini M, Tagliamento M, Pous A, Sita-Lumsden A, Srikandarajah K, Colomba J, Pommeret F, Seguí E, Generali D, Grisanti S, Pedrazzoli P, Rizzo G, Libertini M, Moss C, Evans JS, Russell B, Harbeck N, Vincenzi B, Biello F, Bertulli R, Liñan R, Rossi S, Carmona-García MC, Tondini C, Fox L, Baggi A, Fotia V, Parisi A, Porzio G, Saponara M, Cruz CA, García-Illescas D, Felip E, Roqué Lloveras A, Sharkey R, Roldán E, Reyes R, Earnshaw I, Ferrante D, Marco-Hernández J, Ruiz-Camps I, Gaidano G, Patriarca A, Bruna R, Sureda A, Martinez-Vila C, Sanchez de Torre A, Cantini L, Filetti M, Rimassa L, Chiudinelli L, Franchi M, Krengli M, Santoro A, Prat A, Van Hemelrijck M, Diamantis N, Newsom-Davis T, Gennari A, Cortellini A; OnCovid study group. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study. Lancet Oncol. 2021 Dec;22(12):1669-1680.
  • Carreira S, Porta N, Arce-Gallego S, Seed G, Llop-Guevara A, Bianchini D, Rescigno P, Paschalis A, Bertan C, Baker C, Goodall J, Miranda S, Riisnaes R, Figueiredo I, Ferreira A, Pereira R, Crespo M, Gurel B, Nava Rodrigues D, Pettitt SJ, Yuan W, Serra V, Rekowski J, Lord CJ, Hall E, Mateo J, de Bono JS. Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial. Cancer Discov. 2021 Nov;11(11):2812-2827.
  • Fürstenau M, Fink AM, Schilhabel A, Weiss J, Robrecht S, Eckert R, de la Serna J, Crespo M, Coscia M, Vitale C, Böttcher S, Weppner G, Ritgen M, Stilgenbauer S, Tausch E, Fischer K, Hallek M, Eichhorst B, Brüggemann M, Herling CD. B-cell acute lymphoblastic leukemia in patients with chronic lymphocytic leukemia treated with lenalidomide. Blood. 2021 Apr 22;137(16):2267-2271.
  • Ribera JM, Morgades M, Ciudad J, Montesinos P, Esteve J, Genescà E, Barba P, Ribera J, García-Cadenas I, Moreno MJ, Martínez-Carballeira D, Torrent A, Martínez-Sánchez P, Monsalvo S, Gil C, Tormo M, Artola MT, Cervera M, González-Campos J, Rodríguez C, Bermúdez A, Novo A, Soria B, Coll R, Amigo ML, López-Martínez A, Fernández-Martín R, Serrano J, Mercadal S, Cladera A, Giménez-Conca A, Peñarrubia MJ, Abella E, Vall-Llovera F, Hernández-Rivas JM, Garcia-Guiñon A, Bergua JM, de Rueda B, Sánchez-Sánchez MJ, Serrano A, Calbacho M, Alonso N, Méndez-Sánchez JÁ, García-Boyero R, Olivares M, Barrena S, Zamora L, Granada I, Lhermitte L, Feliu E, Orfao A. Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome-negative adult lymphoblastic leukemia. Blood. 2021 Apr 8;137(14):1879-1894.
  • Bobillo S, Joffe E, Lavery JA, Sermer D, Ghione P, Noy A, Caron PC, Hamilton A, Hamlin PA, Horwitz SM, Kumar A, Matasar MJ, Moskowitz A, Owens CN, Palomba ML, Batlevi CL, Straus D, von Keudell G, Zelenetz AD, Yahalom J, Dogan A, Seshan VE, Younes A. Clinical characteristics and outcomes of extranodal stage I diffuse large B-cell lymphoma in the rituximab era. Blood. 2021 Jan 7;137(1):39-48.
  • Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, Rezvani AR, Karris NA, McGuirk J, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WYK, Koh LP, Keating A, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz G. Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study. Blood. 2021 Oct 21;138(16):1429-1440.
  • Alameda D, Goicoechea I, Vicari M, Arriazu E, Nevone A, Rodriguez S, Lasa M, Puig N, Cedena MT, Alignani D, Garate S, Lara-Astiaso D, Vilas-Zornoza A, Sarvide S, Ocio EM, Lecumberri R, Garcia de Coca A, Labrador J, Gonzalez ME, Palomera L, Gironella M, Cabañas V, Casanova M, Oriol A, Krsnik I, Perez-Montaña A, de la Rubia J, de la Puerta JE, de Arriba F, Fazio VM, Martinez-Lopez J, Lahuerta JJ, Mateos MV, Odero MD, Prosper F, Weiner A, Amit I, Nuvolone M, San Miguel JF, Paiva B. Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development. Blood. 2021 Oct 28;138(17):1583-1589.
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  • Spanish Guidelines for the use of targeted deep sequencing in myelodysplastic syndromes and chronic myelomonocytic leukaemia..Palomo L; Ibáñez M; Abáigar M; Vázquez I; Álvarez S; Cabezón M; Tazón-Vega B; Rapado I; Fuster-Tormo F; Cervera J; Benito R; Larrayoz MJ; Cigudosa JC; Zamora L; Valcárcel D; Cedena MT; Acha P; Hernández-Sánchez JM; Fernández-Mercado M; Sanz G; Hernández-Rivas JM; Calasanz MJ; Solé F; Such E; Spanish Group of MDS (GESMD). 2019.Br J Haematol..
  • The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients.Ribera J; Granada I; Morgades M; Vives S; Genescà E; González C; Nomdedeu J; Escoda L; Montesinos P; Mercadal S; Coll R; González-Campos J; Abella E; Barba P; Bermúdez A; Gil C; Tormo M; Pedreño M; Martínez-Carballeira D; Hernández-Rivas JM; Orfao A; Martínez-López J; Esteve J; Bravo P; Garcia-Guiñon A; Debén G; Moraleda JM; Queizán JA; Ortín X; Moreno MJ; Feliu E; Solé F; Ribera JM; PETHEMA Group, Spanish Society of Haematology. 2019.Br J Haematol.186(2): 263 268.
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  • Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation.Ortí G; García-Cadenas I; López L; Pérez A; Jimenez MJ; Sánchez-Ortega I; Alonso L; Sisinni L; Fox L; Villacampa G; Badell I; de Heredia CD; Parody R; Ferrà C; Solano C; Caballero D; Martino R; Querol S; Valcárcel D. 2019.Bone Marrow Transplant.54(7): 1133 1137.
  • Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study..Escamilla Gómez V; García-Gutiérrez V; López Corral L; García Cadenas I; Pérez Martínez A; Márquez Malaver FJ; Caballero-Velázquez T; González Sierra PA; Viguria Alegría MC; Parra Salinas IM; Calderón Cabrera C; González Vicent M; Rodríguez Torres N; Parody Porras R; Ferra Coll C; Orti G; Valcárcel Ferreiras D; De la Cámara LLanzá R; Molés P; Velázquez-Kennedy K; João Mende M; Caballero Barrigón D; Pérez E; Martino Bofarull R; Saavedra Gerosa S; Sierra J; Poch M; Zudaire Ripa MT; Díaz Pérez MA; Molina Angulo B; Sánchez Ortega I; Sanz Caballer J; Montoro Gómez J; Espigado Tocino I; Pérez-Simón JA; Grupo Español de Trasplante Hematopoyético (GETH). 2019.Bone Marrow Transplant..
  • Deciphering predictive factors for choice of thrombopoietin receptor agonist, treatment free responses, and thrombotic events in immune thrombocytopenia.Lozano ML; Mingot-Castellano ME; Perera MM; Jarque I; Campos-Alvarez RM; González-López TJ; Carreño-Tarragona G; Bermejo N; Lopez-Fernandez MF; de Andrés A; Valcarcel D; Casado-Montero LF; Alvarez-Roman MT; Orts MI; Novelli S; Revilla N; González-Porras JR; Bolaños E; Rodríguez-López MA; Orna-Montero E; Vicente V. 2019.Sci Rep.9(1): 16680 16680.
  • Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.Guglieri-Lopez B; Perez-Pitarch A; Garcia-Cadenas I; Gimenez E; Barba P; Rabella N; Hernandez-Boluda JC; Fox L; Valcarcel D; Esquirol A; Ferriols-Lisart R; Sierra J; Solano C; Navarro D; Martino R; Piñana JL. 2019.Biol Blood Marrow Transplant.25(5): 1022 1030.
  • Thrombopoietin Receptor Agonists for Severe Thrombocytopenia after Allogeneic Stem Cell Transplantation: Experience of the Spanish Group of Hematopoietic Stem Cell Transplant.Bento L; Bastida JM; García-Cadenas I; García-Torres E; Rivera D; Bosch-Vilaseca A; De Miguel C; Martínez-Muñoz ME; Fernández-Avilés F; Roldán E; Chinea A; Yáñez L; Zudaire T; Vaz CP; Espigado I; López J; Valcárcel D; Duarte R; Cabrera R; Herrera C; González-Porras JR; Gutiérrez A; Solano C; Sampol A; Grupo Español de Trasplante Hematopoyético (GETH). 2019.Biol Blood Marrow Transplant.25(9): 1825 1831.
  • Recent Advances in the Targeting of Epigenetic Regulators in B-Cell Non-Hodgkin Lymphoma.Ribeiro ML; Reyes-Garau D; Armengol M; Fernández-Serrano M; Roué G. 2019.Front Genet.10: 986 986.
  • Response-adapted treatment with rituximab, bendamustine, mitoxantrone, and dexamethasone followed by rituximab maintenance in patients with relapsed or refractory follicular lymphoma after first-line immunochemotherapy: Results of the RBMDGELTAMO08 phase II trial..Peñalver FJ; Márquez JA; Durán S; Giraldo P; Martín A; Montalbán C; Sancho JM; Ramírez MJ; Terol MJ; Capote FJ; Gutiérrez A; Sánchez B; López A; Salar A; Rodríguez-Caravaca G; Canales M; Caballero MD; GELTAMO (The Spanish Lymphoma Cooperative Group). 2019.Cancer Med.8(16): 6955 6966.
  • Off-pump technique and replacement therapy for coronary artery bypass surgery in a patient with hemophilia B.Fernández-Caballero M; Martinez MF; Oristrell G; Palmer N; Santamaría A. 2019.J Thromb Thrombolysis.48(2): 299 302.
  • Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia.Ribera J; Zamora L; Morgades M; Vives S; Granada I; Montesinos P; Gómez-Seguí I; Mercadal S; Guàrdia R; Nomdedeu J; Pratcorona M; Tormo M; Martínez-Lopez J; Hernández-Rivas JM; Ciudad J; Orfao A; González-Campos J; Barba P; Escoda L; Esteve J; Genescà E; Solé F; Feliu E; Ribera JM; Spanish PETHEMA Group; Spanish Society of Hematology. 2019.Genes Chromosomes Cancer.58(11): 815 819.
  • Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation.Caballero JC; Sánchez Barba M; Hernández Sánchez JM; Such E; Janusz K; Sanz G; Cabrero M; Chillón C; Cervera J; Hurtado AM; Jerez A; Calderón Cabrera C; Valcárcel D; Lumbreras E; Abáigar M; López Cadenas F; Hernández Rivas JM; Del Cañizo MC; Díez Campelo M. 2019.ANN HEMATOL.98(9): 2151 2162.
  • Safety and efficacy of bosutinib in fourth-line therapy of chronic myeloid leukemia patients..García-Gutiérrez V; Milojkovic D; Hernandez-Boluda JC; Claudiani S; Martin Mateos ML; Casado-Montero LF; González G; Jimenez-Velasco A; Boque C; Martinez-Trillos A; Vázquez IM; Payer ÁR; Senín A; Amustio Díez E; García AB; Carrascosa GB; Ortí G; Ruiz BC; Fernández MÁ; Del Carmen García Garay M; Giraldo P; Guinea JM; De Las Heras Rodríguez N; Hernán N; Pérez AI; Piris-Villaespesa M; Lorenzo JLL; Martí-Tutusaus JMM; Vallansot RO; Ortega Rivas F; Puerta JM; Ramirez MJ; Romero E; Romo A; Rosell A; Saavedra SS; Sebrango A; Tallon J; Valencia S; Portero A; Steegmann JL; Grupo Español de Leucemia Mieloide Crónica (GELMC). 2019.ANN HEMATOL.98(2): 321 330.
  • An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens.Sobas M; Montesinos P; Boluda B; Bernal T; Vellenga E; Nomdedeu J; González-Campos J; Chillón M; Holowiecka A; Esteve J; Bergua J; González-Sanmiguel JD; Gil-Cortes C; Tormo M; Salamero O; Manso F; Fernández I; de la Serna J; Moreno MJ; Pérez-Encinas M; Krsnik I; Ribera JM; Escoda L; Lowenberg B; Sanz MA; PETHEMA, HOVON, PALG, and GATLA cooperative groups. 2019.Leuk Lymphoma.60(4): 1030 1035.
  • Dichotomization of the new revised international prognostic scoring system for a better clinical stratification of patients with myelodysplastic syndromes.Montoro J; Pomares H; Villacampa G; Merchán B; Molero A; Alonso E; Gallur L; Grau J; Salamero O; Roldán E; Saumell S; Ortega M; Sureda A; Bosch F; Arnan M; Valcárcel D.2019.Leuk Lymphoma.60(6): 1522 1527.
  • Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry.Salamero O; Martínez-Cuadrón D; Sobas M; Benavente C; Vives S; De la Serna J; Pérez-Encinas M; Escoda L; Gil C; Brunet S; Ramos F; Esteve J; Amigo M; Krsnik I; Manso F; Arias J; González-Campos J; Serrano J; Oleksiuk J; Barrios M; García-Boyero R; Novo A; Sanz MA; Montesinos P; PETHEMA and PALG Groups. 2019.Leuk Lymphoma.60(11): 2720 2732.
  • Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols..Sobas M; Rodriguez-Veiga R; Vellenga E; Paluszewska M; De la Serna J; García-Álvarez F; Gil C; Brunet S; Bergua J; González-Campos J; Ribera JM; Tormo M; González M; Fernández I; Benavente C; González-Sanmiguel JD; Esteve J; Pérez-Encinas M; Salamero O; Manso F; Lowenberg B; Sanzs MA; Montesinos P; PETHEMA, HOVON, PALG, GATLA cooperative groups. 2019.EUR J HAEMATOL..
  • Frequency, characteristics, and outcome of PTLD after allo-SCT: A multicenter study from the Spanish group of blood and marrow transplantation (GETH).García-Cadenas I; Yáñez L; Jarque I; Martino R; Pérez-Simón JA; Valcárcel D; Sanz J; Bermúdez A; Muñoz C; Calderón-Cabrera C; García E; Alonso L; Suárez-Lledó M; González Vicent M; Heras I; Viguria MC; Batlle M; Vázquez L; López J; Solano C; Spanish group of blood and marrow transplantation (GETH). 2019.EUR J HAEMATOL.102(6): 465 471.
  • Increased survival due to lower toxicity for high-risk T-cell acute lymphoblastic leukemia patients in two consecutive pediatric-inspired PETHEMA trials.Barba P; Morgades M; Montesinos P; Gil C; Fox ML; Ciudad J; Moreno MJ; González-Campos J; Genescà E; Martínez-Carballeira D; Martino R; Vives S; Guardia R; Mercadal S; Artola MT; Cladera A; Tormo M; Esteve J; Bergua J; Vall-Llovera F; Ribera J; Martínez-Sanchez P; Amigo ML; Bermúdez A; Calbacho M; Hernández-Rivas JM; Feliu E; Orfao A; Ribera JM; PETHEMA Group. 2019.EUR J HAEMATOL.102(1): 79 86.
  • Pomalidomide-dexamethasone for treatment of soft-tissue plasmacytomas in patients with relapsed / refractory multiple myeloma..Jiménez-Segura R; Granell M; Gironella M; Abella E; García-Guiñón A; Oriol A; Cabezudo E; Clapés V; Soler JA; Escoda L; López-Pardo J; Fernández de Larrea C; Cibeira MT; Tovar N; Isola I; Bladé J; Rosiñol L; GEMMAC (Grup per l l’estudi del mieloma mútiple i l’amiloïdosi de Catalunya). 2019.EUR J HAEMATOL.102(5): 389 394.
  • Facing real-life with direct oral anticoagulants in patients with nonvalvular atrial fibrillation: outcomes from the first observational and prospective study in a Spanish population.Cerdá M; Cerezo-Manchado JJ; Johansson E; Martínez F; Fernández M; Varela A; Rodríguez S; Bosch F; Santamaría A. 2019.J Comp Eff Res.8(3): 165 178.
  • Allogeneic stem cell transplantationin the era of novel therapies for acute lymphoblastic leukaemia..Barba P; Elorza I. 2019.Med Clin (Barc).153(1): 28 34.
  • Acquired von Willebrand syndrome in a patient with small lymphocytic lymphoma and Sjogren’s syndrome: which associated condition should be prioritized?.Pardos-Gea J; Martínez F; Abrisqueta P; Santamaría A; Bosch F. 2019.Blood Coagul Fibrinolysis.30(5): 239 242.
  • “The TEAM Project” Results on Management of Placenta-Mediated Pregnancy Complications (PMC): The Impact of Thrombophilia Test and Thromboprophylaxis with Low-Molecular-Weight-Heparin on Recurrences of PMC.SANTAMARIA ORTIZ, AMPARO; Martí, Edelmira; Medina, Carmen; Rodríguez, Ana María; Stevenazzi, Mariana; Mira, Yolanda; López, Mertixell; Redondo, Ana Margarita; Aguinaco, Reyes; Sabater, María C; Oliver,
  • Autologous stem cell transplantation may be curative for patients with follicular lymphoma with early therapy failure without the need for immunotherapy..Jiménez-Ubieto A; Grande C; Caballero D; Yáñez L; Novelli S; Hernández-Garcia MT; Manzanares M; Arranz R; Ferreiro JJ; Bobillo S; Mercadal S; Galeo A; Jiménez JL; Moraleda JM; Vallejo C; Albo C; Pérez E; Marrero C; Magnano L; Palomera L; Jarque I; Rodriguez A; Lorza L; Martín A; Coria E; López-Guillermo A; Salar A; José Lahuerta J; GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea) Cooperative Stu. 2019.Hematol Oncol Stem Cell Ther.12(4): 194 203.
  • Thrombosis and hemostasis health in pregnancy: Registries from the International Society on Thrombosis and Haemostasis..Othman M; Santamaría Ortiz A; Cerdá M; Erez O; Minford A; Obeng-Tuudah D; Blondon M; Bistervels I; Middeldorp S; Abdul-Kadir R. 2019.Res Pract Thromb Haemost.3(4): 607 614.
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  • Ruiz-Heredia, Yanira; Sànchez-Vega, Beatriz; Onecha, Esther; Barrio, Santiago; Alonso, Rafael; Martínez-Ávila, Jose Carlos; Cuenca, Isabel; Agirre, Xabier; Braggio, Esteban; Hernández, Miguel-T; Martínez, Rafael; Rosiñol, Laura; Gutierrez, Norma; Martin-Ramos, Marisa; Ocio, Enrique M; Echeveste, María Asunción; Pérez de Oteyza, Jaime; Oriol, Albert; Bargay, Joan; Gironella Mesa, Mercedes; Ayala, Rosa; Bladé, Joan; Mateos, María-Victoria; Kortum, Klaus M; Stewart, Keith; García-Sanz, Ramón; San Miguel, Jesús; Lahuerta, Juan José; Martinez-Lopez, Joaquín. Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing. Haematologica. 2018 Nov 01
  • Bobillo Varelo, Sabela; Abrisqueta Costa, Pau; Carpio Segura, Cecilia; Raheja, Priyanka; Castellví, Josep; Crespo Maull, Marta; Bosch Albareda, Francesc. Promising activity of selinexor in the treatment of a patient with refractory diffuse large B-cell lymphoma and central nervous system involvement. Haematologica. 2018 Feb 01
  • Leblond, Véronique; Aktan, Melih; Ferra Coll, Christelle M; Dartigeas, Caroline; Kisro, Jens; Montillo, Marco; Raposo, João; Merot, Jean-Louis; Robson, Susan; Gresko, Ekaterina; Bosch Albareda, Francesc; Stilgenbauer, Stephan; Foà, Robin. Safety of obinutuzumab alone or combined with chemotherapy for previously untreated or relapsed/refractory chronic lymphocytic leukemia in the phase IIIb GREEN study. Haematologica. 2018 Nov 01
  • Genescà, E; Lazarenkov, A; Morgades, M; Berbis, G; Ruíz-Xivillé, N; Gómez-Marzo, P; Ribera, J; Juncà, J; González-Pérez, A; Mercadal, S; Guardia, R; Artola, M T; Moreno, M J; Martínez-López, J; Zamora, L; Barba Suñol, Pere; Gil, C; Tormo, M; Cladera, A; Novo, A; Pratcorona, M; Nomdedeu, J; González-Campos, J; Almeida, M; Cervera, J; Montesinos, P; Batlle, M; Vives, S; Esteve, J; Feliu, E; Solé, F; Orfao, A; Ribera, J M. Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia. J Hematol Oncol. 2018 Jul 24
  • Esteve-Arenys, A; Valero, J G; Chamorro-Jorganes, A; Gonzalez, D; Rodriguez, V; Dlouhy, I; Salaverria, I; Campo, E; Colomer, D; Martinez, A; Rymkiewicz, G; Pérez-Galán, P; Lopez-Guillermo, A; Roue, Gael. The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma. Oncogene. 2018 Abr 01
  • Blanco, Gonzalo; Vardi, Anna; Puiggros, Anna; Gómez-Llonín, Andrea; Muro, Manuel; Rodríguez-Rivera, María; Stalika, Evangelia; Abella, Eugenia; Gimeno, Eva; López-Sánchez, Manuela; Senín, Alicia; Calvo, Xavier; Abrisqueta Costa, Pau; Bosch Albareda, Francesc; Ferrer, Ana; Stamatopoulos, Kostas; Espinet, Blanca. Restricted T cell receptor repertoire in CLL-like monoclonal B cell lymphocytosis and early stage CLL. Oncoimmunology. 2018 Feb 20
  • Cabezón, Marta; Bargay, Joan; Xicoy, Blanca; García, Olga; Borrás, Josep; Tormo, Mar; Marcé, Sílvia; Pedro, Carme; Valcarcel Ferreiras, David; Jiménez, Maria-José; Guàrdia, Ramón; Palomo, Laura; Brunet, Salut; Vall-Llovera, Ferran; Garcia, Antoni; Feliu, Evarist; Zamora, Lurdes; CETLAM Group. Impact of mutational studies on the diagnosis and the outcome of high-risk myelodysplastic syndromes and secondary acute myeloid leukemia patients treated with 5-azacytidine. Oncotarget. 2018 Abr 10
  • Hernández-Boluda, Juan-Carlos; Correa, Juan-Gonzalo; Alvarez-Larrán, Alberto; Ferrer-Marín, Francisca; Raya, José-María; Martínez-López, Joaquín; Velez, Patricia; Pérez-Encinas, Manuel; Estrada, Natalia; García-Gutiérrez, Valentín; Fox, M. Laura; Luño, Elisa; Kerguelen, Ana; Cuevas, Beatriz; Durán, María-Antonia; Ramírez, María-José; Gómez-Casares, Maite; Mata-Vázquez, María-Isabel; Regadera, Anabel; Pereira, Arturo; Cervantes, Francisco; Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN). Clinical characteristics, prognosis and treatment of myelofibrosis patients with severe thrombocytopenia. British Journal of Haematology. 2018 May 01
  • Goasguen, Jean E; Bennett, John M; Bain, Barbara J; Brunning, Richard; Vallespi Sole, Teresa; Tomonaga, Masao; Zini, Gina; Renault, Alain; (The International Working Group on Morphology of MDS). Dyserythropoiesis in the diagnosis of the myelodysplastic syndromes and other myeloid neoplasms: problem areas. British Journal of Haematology. 2018 Aug 01
  • Gribben, John G; Bosch Albareda, Francesc; Cymbalista, Florence; Geisler, Christian H; Ghia, Paolo; Hillmen, Peter; Moreno, Carol; Stilgenbauer, Stephan. Optimising outcomes for patients with chronic lymphocytic leukaemia on ibrutinib therapy: European recommendations for clinical practice. British Journal of Haematology. 2018 Mar 01
  • Kraaijpoel, Noémie; Di Nisio, Marcello; Mulder, Frits I; van Es, Nick; Beyer-Westendorf, Jan; Carrier, Marc; Garcia, David; Grosso, Michael; Kakkar, Ajay K; Mercuri, Michele F; Middeldorp, Saskia; Hernandez, Cristhiam Rojas;Santamaria Ortiz, Amparo; Schwocho, Lee; Segers, Annelise; Verhamme, Peter; Wang, Tzu-Fei; Weitz, Jeffrey I; Zhang, George; Zwicker, Jeffrey I; Büller, Harry R; Raskob, Gary E. Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study. Thromb Haemostasis. 2018 Aug 01
  • Lozano, Ester; Díaz, Tania; Mena, Mari-Pau; Suñe, Guillermo; Calvo, Xavier; Calderón, Marcos; Pérez-Amill, Lorena; Rodríguez, Vanina; Pérez-Galán, Patricia; Roue, Gael; Cibeira, M Teresa; Rosiñol, Laura; Isola, Ignacio; Rodríguez-Lobato, Luis-Gerardo; Martin-Antonio, Beatriz; Bladé, Joan; Fernández de Larrea, Carlos. Loss of the Immune Checkpoint CD85j/LILRB1 on Malignant Plasma Cells Contributes to Immune Escape in Multiple Myeloma. Journal of Immunology. 2018 Abr 15
  • Ma, Chun Kei Kris; García-Cadenas, Irene; Fox, M. Laura; Ai, Sylvia; Nivison-Smith, Ian; Milliken, Samuel Thomas; Dodds, Anthony; Fay, Keith; Ma, David D F; Martino, Rodrigo; Sierra, Jorge; Moore, John. Poor prognosis in patients with steroid refractory acute graft versus host disease treated with etanercept: a multi-centre analysis. Bone Marrow Transplantation. 2018 Nov 01
  • Jiménez-Ubieto, Ana; Grande, Carlos; Caballero, Dolores; Yáñez, Lucrecia; Hernández-Garcia, Miguel Teodoro; Novelli, Silvana; Arranz, Reyes; Ferreiro, José Javier; Bobillo Varelo, Sabela; Mercadal, Santiago; Galeo, Andrea; Jiménez, Javier López; Moraleda, José María; Vallejo, Carlos; Albo, Carmen; Pérez, Elena; Marrero, Carmen; Magnano, Laura; Palomera, Luis; Jarque, Isidro; Martínez-Sánchez, Pilar; Martín, Alejandro; Coria, Erika; López-Guillermo, Armando; Salar, Antonio; Lahuerta, Juan José; GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea) Cooperative Stu. Secondary malignancies and survival outcomes after autologous stem cell transplantation for follicular lymphoma in the pre-rituximab and rituximab eras: a long-term follow-up analysis from the Spanish GELTAMO registry. Bone Marrow Transplantation. 2018 Jun 01
  • Barba Suñol, Pere; Martino, R.; Zhou, Q.; Cho, C.; Castro-Malaspina, H.; Devlin, S.; Esquirol, A.; Giralt, S.; Jakubowski, A.A.; Caballero, D.; Maloy, M.; Papadopoulos, E.B.; Piñana, J.L.; Fox, M. Laura; Márquez, F.; Valcarcel Ferreiras, David; Solano, C.; López-Corral, L.; Sierra, J.; Perales, M.-A.. CD34 + Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age 50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome. Biology of Blood and Marrow Transplantation. 2018 May 01
  • Mestre-Torres, Jaume; Lorenzo-Bosquet, Carles; Cuberas-Borrós, Gemma; Gironella Mesa, Mercedes; Solans-Laque, Roser; Fernández-Codina, Andreu; Bujan-Rivas, Segundo; Castell-Conesa, Joan; Martínez-Valle, Fernando. Utility of the 18 F-Florbetapir positron emission tomography in systemic amyloidosis. Amyloid. 2018 Jun 01
  • Riveiro-Barciela, Mar; Bes, Marta; Quer, Josep; Valcarcel Ferreiras, David; Piriz, Sofia; Gregori, Josep; Llorens, Meritxell; Salcedo, María-Teresa; Piron, Maria; Esteban, Rafael; Buti, Maria; Sauleda, Silvia. Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin. Transfusion. 2018 Nov 01
  • Jiménez-Ubieto, Ana; Grande, Carlos; Caballero, Dolores; Yáñez, Lucrecia; Novelli, Silvana; Hernández-Garcia, Miguel Teodoro; Manzanares, María; Arranz, Reyes; Ferreiro, José Javier; Bobillo Varelo, Sabela; Mercadal, Santiago; Galeo, Andrea; Jiménez, Javier López; Moraleda, José María; Vallejo, Carlos; Albo, Carmen; Pérez, Elena; Marrero, Carmen; Magnano, Laura; Palomera, Luis; Jarque, Isidro; Martínez-Sánchez, Pilar; Martín, Alejandro; Coria, Erika; López-Guillermo, Armando; Salar, Antonio; Lahuerta, Juan José; GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea) Cooperative Stu. Autologous stem cell transplantation may be curative for patients with follicular lymphoma with early therapy failure who reach complete response after rescue treatment. Hematological Oncology. 2018 Des 01
  • Martínez-Cuadrón, David; Boluda, Blanca; Martínez, Pilar; Bergua, Juan; Rodríguez-Veiga, Rebeca; Esteve, Jordi; Vives, Susana; Serrano, Josefina; Vidriales, Belen; Salamero Garcia, Olga; Cordón, Lourdes; Sempere, Amparo; Jiménez-Ubieto, Ana; Prieto-Delgado, Julio; Díaz-Beyá, Marina; Garrido, Ana; Benavente, Celina; Pérez-Simón, José Antonio; Moscardó, Federico; Sanz, Miguel A; Montesinos, Pau; CETLAM and PETHEMA groups. A phase I-II study of plerixafor in combination with fludarabine, idarubicin, cytarabine, and G-CSF (PLERIFLAG regimen) for the treatment of patients with the first early-relapsed or refractory acute myeloid leukemia. Annals of Hematology. 2018 May 01
  • Montoro Gomez, Julia; Gallur Cuenca, Laura;Merchan Ruiz, Brayan Marcel; Molero, Antonieta; Roldán, Elisa; Martínez-Valle, Ferrán; Villacampa, Guillermo; Navarrete, Mayda; Ortega Blanco, Margarita; Castellví, Josep; Saumell, Silvia; Bobillo Varelo, Sabela; Bosch Albareda, Francesc; Valcarcel Ferreiras, David. Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes. Annals of Hematology. 2018 Aug 01
  • Bobillo Varelo, Sabela; Abrisqueta Costa, Pau; Sánchez-González, B; Giné, E; Romero, S; Alcoceba, M; González-Barca, E; González de Villambrosía, S; Sancho, J M; Gomez Pardo, Patricia; Bento, L; Montoro Gomez, Julia; Montes, S; Lopez Hernandez, Andres; Bosch Albareda, Francesc; Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea (GEL/TAMO cooperati. Posttransplant monomorphic Burkitt’s lymphoma: clinical characteristics and outcome of a multicenter series. Annals of Hematology. 2018 Des 01
  • Hernández-Boluda, Juan-Carlos; Pereira, Arturo; Correa, Juan-Gonzalo; Alvarez-Larrán, Alberto; Ferrer-Marín, Francisca; Raya, José-María; Martínez-López, Joaquín; Velez, Patricia; Pérez-Encinas, Manuel; Estrada, Natalia; García-Gutiérrez, Valentín; Fox, M. Laura; Payer, Angel; Kerguelen, Ana; Cuevas, Beatriz; Durán, María-Antonia; Ramírez, María-José; Gómez-Casares, María-Teresa; Mata-Vázquez, María-Isabel; Mora, Elvira; Gómez, Montse; Cervantes, Francisco. Prognostic risk models for transplant decision-making in myelofibrosis. Annals of Hematology. 2018 May 01
  • Colonna, Paolo; von Heymann, Christian; Santamaria Ortiz, Amparo; Matsushita, Yasuyuki; Unverdorben, Martin. Edoxaban Management in Diagnostic and Therapeutic Procedures (EMIT-AF/VTE)-Trial design. Clin Cardiol. 2018 Sep 01
  • Body, Simon; Esteve-Arenys, Anna; Recasens-Zorzo, Clara; Troussard, Xavier; Roue, Gael; Sola, Brigitte. A mouse model of disseminated mantle cell lymphoma highlights a lack of activity of estrogen receptor ß agonists toward tumor burden. Leukemia & Lymphoma. 2018 Jul 01
  • Guillem, Vicent; Calabuig, Marisa; Brunet, Salut; Esteve, Jordi; Escoda, Lourdes; Gallardo, David; Ribera, Josep-Maria; Queipo de Llano, María Paz; Arnan, Montserrat; Pedro, Carme; Amigo, María Luz; Martí-Tutusaus, Josep M; García-Guiñón, Antoni; Bargay, Joan; Sampol, Antonia; Salamero Garcia, Olga; Font, Llorenç; Talarn, Carme; Hoyos, Montserrat; Díaz-Beyá, Marina; Garrido, Ana; Navarro, Blanca; Nomdédeu, Josep; Sierra, Jordi; Tormo, Mar. Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival. Leukemia & Lymphoma. 2018 Oct 01
  • González-Gascón Y Marín, Isabel; Hernández-Sanchez, María; Rodríguez-Vicente, Ana Eugenia; Puiggros, Anna; Collado, Rosa; Luño, Elisa; González, Teresa; Ruiz-Xivillé, Neus; Ortega Blanco, Margarita; Gimeno, Eva; Muñoz, Carolina; Infante, Maria Stefania; Delgado, Julio; Vargas, María Teresa; González, Marcos; Bosch Albareda, Francesc; Espinet, Blanca; Hernández-Rivas, Jesús María; Hernández, José Ángel; Grupo Español de Leucemia Linfática Crónica (GELLC) and Grupo Cooperativo Españo. Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia. Leukemia & Lymphoma. 2018 Mar 01
  • Ribera, Josep-Maria; Morgades, Mireia; Montesinos, Pau; Martino, Rodrigo; Barba Suñol, Pere; Soria, Beatriz; Bermúdez, Arancha; Moreno, María-José; González-Campos, José; Vives, Susana; Gil, Cristina; Abella, Eugenia; Guàrdia, Ramon; Martínez-Carballeira, Daniel; Martínez-Sánchez, Pilar; Amigo, María-Luz; Mercadal, Santiago; Serrano, Alfons; López-Martínez, Aurelio; Vall-Llovera, Ferran; Sánchez-Sánchez, María-José; Peñarrubia, María-Jesús; Calbacho, María; Méndez, Jose-Angel; Bergua, Juan; Cladera, Antonia; Tormo, Mar; García-Belmonte, Daniel; Feliu, Evarist; Ciudad, Juana; Orfao, Alberto; Valcarcel Ferreiras, David. Efficacy and safety of native versus pegylated Escherichia coli asparaginase for treatment of adults with high-risk, Philadelphia chromosome-negative acute lymphoblastic leukemia. Leukemia & Lymphoma. 2018 Jul 01
  • Sole, Carla; Martinez, Daniel; Gine, Eva; Gonzalez-Farre, Blanca; Perez-Galan, Patricia; Roncador, Giovanna; Campo, Elias; Matutes, Estela; Lopez-Guillermo, Armando; Roue, Gael; Martinez, Antonio. Expression of a truncated B lymphocyte-induced maturation protein-1 isoform is associated with an incomplete plasmacytic differentiation program in chronic lymphocytic leukemia. Leukemia & Lymphoma. 2018 Jan 01
  • Motlló, Cristina; Ribera, Josep-Maria; Morgades, Mireia; Granada, Isabel; Montesinos, Pau; Mercadal, Santiago; González-Campos, José; Moreno, María-José; Barba Suñol, Pere; Cervera, Marta; Barrios, Manuel; Novo, Andrés; Bernal, Teresa; Hernández-Rivas, Jesús-María; Abella, Eugenia; Amigo, María-Luz; Tormo, Mar; Martino, Rodrigo; Lavilla, Esperanza; Bergua, Juan; Serrano, Alfons; García-Belmonte, Daniel; Guàrdia, Ramon; Grau, Javier; Feliu, Evarist; PETHEMA Group, Spanish Society of Hematology. Frequency and prognostic significance of additional cytogenetic abnormalities to the Philadelphia chromosome in young and older adults with acute lymphoblastic leukemia. Leukemia & Lymphoma. 2018 Jan 01
  • Baptista, Maria Joao; Tapia, Gustavo; Morgades, Mireia; Muncunill, Josep; Muñoz-Marmol, Ana-María; Montoto, Silvia; Gribben, John G; Calaminici, Maria; Martinez, Antonio; Gonzalez-Farre, Blanca; Dlouhy, Ivan; González-Barca, Eva; Terol, María-José; Miralles, Pilar; Alcoceba, Miguel; Vall-Llovera, Ferran; Briones, Javier; Abrisqueta Costa, Pau; Abella, Eugenia; Provencio, Mariano; García-Ballesteros, Carlos; Moraleda, José-María; Sancho, Juan-Manuel; Ribera, Josep-Maria; Mate, José-Luis; Navarro, José-Tomas. Using the Lymph2Cx assay for assessing cell-of-origin subtypes of HIV-related diffuse large B-cell lymphoma. Leukemia & Lymphoma. 2018 Oct 15 (Epub ahead of print)
  • Bosch-Vilaseca, Anna; García-Cadenas, Irene; Roldán, Elisa; Novelli, Silvana; Barba Suñol, Pere; Esquirol, Albert; Valcarcel Ferreiras, David; Martino, Rodrigo; Sierra, Jorge. Usefulness of thrombopoietin receptor agonists for persistent clinically relevant thrombocytopenia after allogeneic stem cell transplantation. European Journal of Haematology. 2018 Sep 01
  • Larrainzar-Coghen, Thais; Rodríguez-Pardo, Dolors; Barba Suñol, Pere; Aguilar Company, Juan; Rodríguez, Virginia; Roig, Gloria; Ferrer, Carmen; Ruiz-Camps, Isabel; Almirante, Benito. Prognosis of Clostridium difficile infection in adult oncohaematological patients: experience from a large prospective observational study. European Journal of Clinical Microbiology & Infectious Diseases. 2018 Nov 01
  • Orti, Guillermo; Sanz, Jaime; García-Cadenas, Irene; Sánchez-Ortega, Isabel; Alonso, Laura; Jiménez, Maria José; Sisinni, Luisa; Azqueta, Carmen; Salamero Garcia, Olga; Badell, Isabel; Ferra, Christelle; de Heredia, Cristina Diaz; Parody, Rocio; Sanz, Miguel Angel; Sierra, Jorge; Piñana, Jose Luis; Querol, Sergi; Valcarcel Ferreiras, David. Analysis of relapse after transplantation in acute leukemia: A comparative on second allogeneic hematopoietic cell transplantation and donor lymphocyte infusions. Experimental Hematology. 2018 Jun 01
  • Yeung, Cecilia Cs; Hockenbery, David M; Westerhoff, Maria; Coutre, Steven E; Sedlak, Ruth H; Dubowy, Ronald L; Munugalavadla, Veerendra; Taylor, Kerry; Bosch Albareda, Francesc. Pathological assessment of gastrointestinal biopsies from patients with idelalisib-associated diarrhea and colitis. Future Oncology. 2018 Sep 01
  • Piedra-Carrasco, Nuria; Miguel, Lucia; Fàbrega, Anna; Viñado, Belén; Campany, David; Mir, Alba; Fox, M. Laura; Almirante, Benito; Larrosa, Nieves; Ruiz-Camps, Isabel; González-López, Juan José. Effectiveness of a Double-Carbapenem Regimen in a KPC-Producing Klebsiella pneumoniae Infection in an Immunocompromised Patient. Microbial Drug Resistance. 2018 Mar 01
  • Ribera, Josep-Maria; García, Olga; Gil, Cristina; Mercadal, Santiago; García-Cadenas, Irene; Montesinos, Pau; Barba Suñol, Pere; Vives, Susana; González-Campos, José; Tormo, Mar; Esteve, Jordi; Lopez Hernandez, Andres; Moreno, María José; Ribera, Jordi; Alonso, Natalia; Bermúdez, Arancha; Amigo, María Luz; Genescà, Eulàlia; García, Daniel; Vall-Llovera, Ferran; Bergua, Juan Miguel; Guàrdia, Ramon; Monteserín, María Carmen; Bernal, Teresa; Calbacho, María; Martínez, María Pilar; Feliu, Evarist; Valcarcel Ferreiras, David. Comparison of intensive, pediatric-inspired therapy with non-intensive therapy in older adults aged 55-65 years with Philadelphia chromosome-negative acute lymphoblastic leukemia. Leukemia Research. 2018 May 01
  • Miyazaki, Yasushi; Tuechler, Heinz; Sanz, Guillermo; Schanz, Julie; Garcia-Manero, Guillermo; Solé, Francesc; Bennett, John M; Bowen, David; Fenaux, Pierre; Dreyfus, Francois; Kantarjian, Hagop; Kuendgen, Andrea; Malcovati, Luca; Cazzola, Mario; Cermak, Jaroslav; Fonatsch, Christa; Le Beau, Michelle M; Slovak, Marilyn L; Santini, Valeria; Lübbert, Michael; Maciejewski, Jaroslaw; Machherndl-Spandl, Sigrid; Magalhaes, Silvia M M; Pfeilstöcker, Michael; Sekeres, Mikkael A; Sperr, Wolfgang R; Stauder, Reinhard; Tauro, Sudhir; Valent, Peter; Vallespi Sole, Teresa; van de Loosdrecht, Arjan A; Germing, Ulrich; Haase, Detlef; Greenberg, Peter L. Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes: Analysis from the International Working Group for Prognosis of MDS. Leukemia Research. 2018 Oct 01
  • Xicoy, Blanca; Triguero, Ana; Such, Esperanza; García, Olga; Jiménez, María-José; Arnán, Montserrat; Bernal, Teresa; Diaz-Beya, Marina; Valcarcel Ferreiras, David; Pedro, Carme; Ramos, Fernando; Amigo, María-Luz; Collado, Rosa; Palomo, Laura; Ardanaz, María-Teresa; Cedena, María-Teresa; Grau, Javier; Zamora, Lurdes; Sanz, Guillermo. The division of chronic myelomonocytic leukemia (CMML)-1 into CMML-0 and CMML-1 according to 2016 World Health Organization (WHO) classification has no impact in outcome in a large series of patients from the Spanish group of MDS. Leukemia Research. 2018 May 09
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  • Update of the Grupo Español de Leucemia Linfocítica Crónica clinical guidelines of the management of chronic lymphocytic leukemia. García-Marco JA; Delgado J; Hernández-Rivas JA; Ramírez Payer Á; Loscertales Pueyo J; Jarque I; Abrisqueta P; Giraldo P; Martínez R; Yáñez L; Terol MJ; González M; Bosch F; en nombre del Grupo Español de Leucemia Linfocítica Crónica (GELLC). 2017.Med Clin (Barc).148: 3811-3819.
  • Bridge therapy in patients under anticoagulation: Is it still the question? Santamaría A. 2017.Med Clin (Barc).149: 303-304.
  • Analytical parameters and vital signs in patients subjected to dental extraction. Jané-Pallí E; Arranz-Obispo C; González-Navarro B; Murat J; Ayuso-Montero R; Rojas S; Santamaría A; Jané-Salas E; López-López J. 2017.J Clin Exp Dent.
  • Single umbilical cord blood with or without CD34+ cells from a third-party donor in adults with leukemia. Sanz J; Kwon M; Bautista G; Sanz MA; Balsalobre P; Piñana JL; Solano C; Duarte R; Ferrá C; Lorenzo I; Martín C; Barba P; Pascual MJ; Martino R; Gayoso J; Buño I; Regidor C; de la Iglesia A; Montoro J; Díez-Martín JL; Sanz GF; Cabrera R. 2017.Blood Adv.1: 1047-1055.
  • Noelia Purroy; Júlia Carabia; Pau Abrisqueta; Leire Egia; Meritxell Aguiló; Cecilia Carpio; Carles Palacio; Marta Crespo; Francesc Bosch. Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells. Oncotarget. 2017 Jan 3;8(1):742-756
  • Orti G; Barba P; Fox L; Salamero O; Bosch F; Valcarcel D. Donor Lymphocyte Infusions in AML and MDS:enhancing the Graft-versus-Leukemia effect. Experimental Hematology. 24/12/2016. [Epub ahead of print]
  • Blanco G; Puiggros A; Baliakas P; Athanasiadou A; García-Malo M; Collado R; Xochelli A; Rodríguez-Rivera M; Ortega M; Calasanz MJ; Luño E; Vargas M; Grau J; Martínez-Laperche C; Valiente A; Cervera J; Anagnostopoulos A; Gimeno E; Abella E; Stalika E; Hernández-Rivas JM; Ortuño FJ; Robles D; Ferrer A; Ivars D; González M; Bosch F; Abrisqueta P; tamatopoulos K; Espinet B. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget. 2016 Dec 6;7(49):80916-80924
  • Städler N; Shang A; Bosch F; Briggs A; Goede V; Berthier A; Renaudin C. A Systematic Review and Network Meta-Analysis to Evaluate the Comparative Efficacy of Interventions for Unfit Patients with Chronic LymphocyticLeukemia. Advanced Therapies. 33(10), pp. 1814 – 1830. 03/10/2016.
  • González-Gascón Y Marín I; Hernández-Sánchez M; Rodríguez-Vicente AE; Sanzo C; Aventín A; Puiggros A; Collado R; Heras C; Muñoz C; Delgado J; Ortega M; González MT; Marugán I; de la Fuente I; Recio I; Bosch F; Espinet B; González M; Hernández-Rivas JM; Hernández JÁ;; On behalf of Grupo Español de Leucemia Linfática Crónica (GELLC); Grupo Cooperativo Español de Citogenética Hematológica (GCECGH). A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemia. Hematol Oncol. 2016 Jun;34(2):84-92
  • Bär C; Povedano JM; Serrano R; Benitez-Buelga C; Popkes M; Formentini I; Bobadilla M; Bosch F; Blasco MA. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia. Blood. 127 – 14, pp. 1770 – 1779. 07/04/2016.
  • Rawstron AC; Fazi C; Agathangelidis A; Villamor N; Letestu R; Nomdedeu J; Palacio C; Stehlikova O; Kreuzer KA; Liptrot S; O’Brien D; de Tute RM; Marinov I; Hauwel M; Spacek M; Dobber J; Kater AP; Gambell P; Soosapilla A; Lozanski G; Brachtl G; Lin K; , Boysen J; Hanson C; Jorgensen JL; Stetler-Stevenson M; Yuan C; Broome HE; Rassenti L; Craig F; Delgado J; Moreno C; Bosch F; Egle A; Doubek M; Pospisilova S; Mulligan S; Westerman D; Sanders CM; Emerson R; Robins HS; Kirsch I; Shanafelt T; Pettitt A; Kipps TJ; Wierda WG; Cymbalista F; Hallek M; Hillmen P; Montserrat E. A complementary role of multiparameter flow-cytometry and high-throughput sequencing for minimal residual disease (MRD) detection in chronic lymphocytic leukemia (CLL): An European research initiative on CLL (ERIC) study. Leukemia. 2016 Apr;30(4):929-36.
  • Pons V; Olivera P; García-Consuegra R,; López-Andreoni L; Martín-Begué N; García A, Hidalgo J,; Bosch F; Santamaría A. Beyond hemostasis: the challenge of treating plasminogen deficiency. A report of three cases. J Thromb Thrombolysis. 2016 Apr;41(3):544-7
  • Hernández JÁ; Hernández-Sánchez M; Rodríguez-Vicente AE; Grossmann V; Collado R; Heras C; Puiggros A; Martín AÁ; Puig N; Benito R; Robledo C; Delgado J; González T; Queizán JA; Galende J; de la Fuente I; Martín-Núñez G; Alonso JM; Abrisqueta P; Luño E; Marugán I; González-Gascón I; Bosch F; Kohlmann A; González M; Espinet B; Hernández-Rivas JM. A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia. PLoS One. 2015 Dec 2;10(11):e0143073.
  • Riveiro-Barciela M; Artaza G; Abrisqueta P; Bosch F; Buti M. Importance of hepatitis B virus screening in hematological patients. Gastroenterol Hepatol. 2015 Nov;38(9):563-4
  • Purroy N; Abrisqueta P; Carabia J; Carpio C; Palacio C; Bosch F; Crespo M. Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo. Oncotarget. 2015 Apr 10;6(10):7632-43.
  • Purroy N; Abrisqueta P; Carabia J; Carpio C; Calpe E; Palacio C; Castellví J; Crespo M; Bosch F. Targeting the proliferative and chemoresistant compartment in chronic lymphocytic leukemia by inhibiting survivin protein. Leukemia. 28 – (10), pp. 1993 – 2004.
  • Maria Joao Baptista; Eva Calpe; Eva Fernández; Lluis Colomo; Teresa Marta Cardesa-Salzmann; Pau Abrisqueta; Francesc Bosch; Marta Crespo. Analysis of the IGHV region in Burkitt’s lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis. Leuk Res. 2014 Apr;38(4):509-15
  • Barba P; Martino R; Pérez-Simón JA; Fernández-Avilés F; Castillo N; Piñana JL; López-Anglada L; Rovira M; Bosch F; Carreras E; Corral LL; Sierra J; Valcárcel D. Combination of the Hematopoietic Cell Transplantation Comorbidity Index and the European Group for Blood and Marrow Transplantation Score Allows a Better Stratification of High-Risk Patients Undergoing Reduced-Toxicity Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2014 Jan;20(1):66-72
  • Abrisqueta P; Villamor M; Terol MJ; González- Barca E; Ferrà C; Abella E; Delgado J; Garcia-Marco JA; Gonzalez Y; CarbonellF; Monzo E; Jarque I; Muntañola A; Constants M; Escoda L; Calvo X; Bobillo S; Montoro JB; Montserrat E; Bosch F. Rituximab maintenance after first-line therapy with rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) for chronic lymphocytic leukemia. Blood. 2013 Dec 5;122(24):3951-9.05/12/2013.
  • Calpe E; Purroy N; Carpio C; Abrisqueta P; Carabia J; Palacio C; Castellví J; Crespo M; Bosch F.ZAP-70 Promotes the Infiltration of Malignant B-Lymphocytes into the Bone Marrow by Enhancing Signaling and Migration after CXCR4 Stimulation. PLoS One. 2013 Dec 3;8(12):e81221.
  • Puiggros A; DelgadoJ; Rodriguez- Vicente A; Collado R; Aventín A; Luño E; Luño E; Grau J; Hernandez JÁ; Marugán I; Ardanaz M; González T; Valiente A; Osma M; Calasanz MJ; Sanzo C; Carrió A; Ortega M; Santacruz R; Abrisqueta P; Abella E; Bosch F; Carbonell F; Solé F; Hernández JM; Espinet B. Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion. Br J Haematol. 2013 Oct;163(1):47-54
  • Mora D; Barba P; Castillo N; Aizpurua M; Rosellé E; Bosch F; Valcárcel D. Primary gastrointestinal aspergillosis 6 months after allogeneic hematopoietic cell transplantation: a case report. Transpl Infect Dis. 2013 Jun;15(3):E107-10
  • Villamor N; Conde L; Martínez-Trillos A; Cazorla M; Navarro A; Beà S; López C; Colomer D; Pinyol M; Aymerich, M; Rozman M; Abrisqueta P; Baumann T; Delgado J; Giné E; González-Díaz M; Hernández JM; Colado E; Payer AR; Rayon C; Navarro B; José Terol M; Bosch F; Quesada V; Puente XS; López-Otín C; Jares P; Pereira A; Campo E; López-Guillermo A. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia. 2013 Abr; 27(5): 1100 – 1106.
  • Baptista MJ, Muntanola A, Calpe E, Abrisqueta P, Salamero O, Fernandez E, Codony C, Gine E, Kalko SG, Crespo M, Bosch F. Differential Gene Expression Profile Associated to Apoptosis Induced by Dexamethasone in CLL Cells According to IGHV/ZAP-70 Status. Clin Cancer Res. 2012 Sep;18(21):5924-33.
  • Wendtner CM, Hillmen P, Mahadevan D, Bühler A, Uharek L, Coutré S, Frankfurt O, Bloor A, Bosch F, Furman RR, Kimby E, Gribben JG, Gobbi M, Dreisbach L, Hurd DD, Sekeres MA, Ferrajoli A, Shah S, Zhang J, Moutouh-de Parseval L, Hallek M, Heerema NA, Stilgenbauer S, Chanan-Khan AA. Final results of a multicenter phase 1 study of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia. Leuk Lymph. 2012 Mar;53(3):417-23.
  • Montagut C, Dalmases A, Bellosillo B, Crespo M, Pairet S, Iglesias M, Salido M, Gallen M, Marsters S, Tsai SP, Minoche A, Somasekar S, Serrano S, Himmelbauer H, Bellmunt J, Rovira A, Settleman J, Bosch F, Albanell J. Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer. Nat Med. 2012 Jan 22;18(2):221-3
  • Calpe E, Codony C, Baptista MJ, Abrisqueta P, Del Carpio C, Purroy N, Bosch F, Crespo M. ZAP-70 enhances migration of malignant B lymphocytes towards CCL21 by inducing CCR7 expression via IgM-ERK1/2 activation. Blood 2011 Oct 20; 111(16): 4401-10- 2011.
  • Antón A, López-Iglesias AA, Tórtola T, Ruiz-Camps I, Abrisqueta P, Llopart L, Marcos MÁ, Martínez MJ, Tudó G, Bosch F, Pahissa A, de Anta MT, Pumarola T. Selection and viral load kinetics of an oseltamivir-resistant pandemic influenza A (H1N1) virus in an immunocompromised patient during treatment with neuraminidase inhibitors. Diagn Microbiol Infect Dis. 2010 Nov;68(3):214-9.
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  • Giné E, Martinez A, Villamor N, López-Guillermo A, Camos M, Martinez D, Esteve J, Calvo X, Muntañola A, Abrisqueta P, Rozman M, Rozman C, Bosch F, Campo E, Montserrat E. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behavior. Haematologica. 2010 Sep; 95(9):1526-33.
  • Gutiérrez-García G, Colomo L, Villamor N, Arenillas L, Martínez A, Cardesa T, García-Herrera A, Setoain X, Rodríguez S, Ghita G, Abrisqueta P, Giné E, Bosch F, Campo E, Montserrat E, López-Guillermo A. Clinico-biological characterization and outcome of primary nodal and extranodal diffuse large B-cell lymphoma in the rituximab era. Leuk Lymph. 2010 Jul;51(7):1225-32
  • Fernández de Larrea C, Martínez C, Gaya A, López-Guillermo A, Rovira M,Fernández-Avilés F, Lozano M, Bosch F, Esteve J, Nomdedeu B, Montserrat E, Carreras E. Salvage chemotherapy with alternating MINE-ESHAP regimen in relapsed or refractory Hodgkin’s lymphoma followed by autologous stem-cell transplantation. Ann Oncol. 2010 Jun;21(6):1211-6.
  • Fernàndez V, Salamero O, Espinet B, Solé F, Royo C, Navarro A, Camacho F, Beà S, Hartmann E, Amador V, Hernández L, Agostinelli C, Sargent RL, Rozman M, Aymerich M, Colomer D, Villamor N, Swerdlow SH, Pileri SA, Bosch F, Piris MA, Montserrat E, Ott G, Rosenwald A, López-Guillermo A, Jares P, Serrano S, Campo E. Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma. Cancer Res. 2010 Feb 15; 70(4):1408-18
  • Bosch F, Abrisqueta P, Villamor N, Terol MJ, González-Barca E, Ferra C, González Diaz M, Abella E, Delgado J, Carbonell F, García Marco JA, Escoda L, Ferrer S, Monzó E, González Y, Estany C, Jarque I, Salamero O, Muntañola A, Montserrat E. Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: a new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia. J Clin Oncol. 2009 Sep 20;27(27):4578-84.
  • Abrisqueta P, Pereira A, Rozman C, Aymerich M, Giné E, Moreno C, Muntañola A,Rozman M, Villamor N, Hodgson K, Campo E, Bosch F, Montserrat E. Improving survival in patients with chronic lymphocytic leukemia (1980-2008): the Hospital Clinic of Barcelona experience. Blood. 2009 Sep 3;114(10):2044-50
  • Hartmann E, Fernàndez V, Moreno V, Valls J, Hernández L, Bosch F, Abrisqueta P, Klapper W, Dreyling M, Hoster E, Müller-Hermelink HK, Ott G, Rosenwald A, Campo E. Five-Gene Model to Predict Survival in Mantle-Cell Lymphoma Using Frozen or Formalin-Fixed, Paraffin-Embedded Tissue. J Clin Oncol. 2008 Oct 20;26(30):4966-72.
  • Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Cancer Res. 2008 Dec 15;68(24):10178-86.
  • Giné E, Crespo M, Muntañola A, Calpe E, Baptista MJ, Villamor N, Montserrat E, Bosch F. Induction of histone H1.2 cytosolic release in chronic lymphocytic leukemia cells after genotoxic and non-genotoxic treatment. Haematologica. 2008 Jan; 93(1):75-82.
  • Fernàndez V, Jares P, Salaverria I, Giné E, Beà S, Aymerich M, Colomer D, Villamor N, Bosch F, Montserrat E, Campo E. Gene expression profile and genomic changes in disease progression of early-stage chronic lymphocytic leukemia. Haematologica. 2008 Jan; 93(1):132-6.
  • Bosch F, Ferrer A, Villamor N, González M, Briones J, González-Barca E, Abella E, Gardella S, Escoda L, Pérez-Ceballos E, Asensi A, Sayas MJ, Font L, Altés A, Muntañola A, Bertazzoni P, Rozman M, Aymerich M, Giné E, Montserrat E. Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication. Clin Cancer Res. 2008 Jan 1; 14(1):155-61.
  • Ferrer A, Bosch F, Villamor N, Rozman M, Graus F, Gutiérrez G, Mercadal S, Campo E, Rozman C, López-Guillermo A, Montserrat E. Central nervous system involvement in mantle cell lymphoma. Ann Oncol. 2008 Jan;19(1):135-41.
  • Ferrer A, Salaverria I, Bosch F, Villamor N, Rozman M, Bea S, Gine E, Lopez-Guillermo A, Campo E, Montserrat E. Leukemic involvement is a common feature in mantle cell lymphoma. Cancer 2007; 109:2473-80
  • Muntañola A, Bosch F, Arguis P, Arellano-Rodrigo E, Ayuso C, Gine E, Crespo M, Abrisqueta P, Moreno C, Cobo F, Lopez-Guillermo A, Montserrat E. Abdominal Computed Tomography Predicts Progression in Patients With Rai Stage 0 Chronic Lymphocytic. Leukemia. J Clin Oncol 2007; 25:1576-80
  • Wiestner A, Tehrani M, Chiorazzi M, Wright G, Gibellini F, Nakayama K, Liu H, Rosenwald A, Muller-Hermelink HK, Ott G, Chan WC, Greiner TC, Weisenburger DD, Vose JM, Armitage JO, Gascoyne RD, Connors JM, Campo E, Montserrat E, Bosch F, Smeland EB, Kvaloy S, Holte H, Delabie J, Fisher RI, Grogan TM, Miller TP, Wilson WH, Jaffe ES, Staudt LM. Point mutations and genomic deletions in Cyclin D1 create stable truncated mRNAs that are associated with increased proliferation rate and shorter survival in mantle cell lymphoma. Blood. 2007;109(11):4599-606.
  • Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, Smilevska T, Belhoul L, Stella S, Stavroyianni N, Crespo M, Hadzidimitriou A, Sutton L, Bosch F, Laoutaris N, Anagnostopoulos A, Montserrat E, Fassas A, Dighiero G, Caligaris-Cappio F, Merle-Beral H, Ghia P, Davi F. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007; 109:259-70
  • Giné E, Montoto S, Bosch F, Arenillas L, Mercadal S, Villamor N, Martínez A, Colomo L, Campo E, Montserrat E, López-Guillermo A. The Follicular Lymphoma International Prognostic Index (FLIPI) and the histological subtype are the most important factors to predict histological transformation in follicular lymphoma. Ann Oncol. 2006 Oct;17(10):1539-45
  • Bosch F, Muntanola A, Gine E, Carrio A, Villamor N, Moreno C, Crespo M, Montserrat E. Clinical implications of ZAP-70 expression in chronic lymphocytic leukemia. Cytometry B Clin Cytom 2006; 70:214-7
  • Moreno C, Villamor N, Colomer D, Esteve J, Gine E, Muntanola A, Campo E, Bosch F, Montserrat E. Clinical significance of minimal residual disease, as assessed by different techniques, after stem-cell transplantation for chronic lymphocytic leukemia. Blood 2006; 107: 4563-9
  • Marce S, Balague O, Colomo L, Martinez A, Holler S, Villamor N, Bosch F, Ott G, Rosenwald A, Leoni L, Esteller M, Fraga MF, Montserrat E, Colomer D, Campo E. Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clin Cancer Res 2006; 12:3754-61.
  • Montserrat E, Moreno C, Esteve J, Urbano-Ispizua A, Gine E, Bosch F. How I treat refractory CLL. Blood; 2006; 107:1276-83
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  • Plancarte F, Lopez-Guillermo A, Arenillas L, Montoto S, Gine E, Muntanola A, Ferrer A, Villamor N, Bosch F, Colomo L, Balaguer O, Campo E, Montserrat E. Follicular lymphoma in early stages: high risk of relapse and usefulness of the Follicular Lymphoma International Prognostic Index to predict the outcome of patients. Eur J Haematol 2006 76:58-63
  • Moreno C, Villamor N, Colomer D, Esteve J, Martino R, Nomdedeu J, Bosch F, López-Guillermo A, Campo E, Sierra J, Montserrat E. Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia. J Clin Oncol 2005;23(15):3433-8
    López-Guillermo A, Colomo L, Jiménez L, Bosch F, Villamor N, Arenillas L, Muntañola A, Montoto S, Giné E, Colomer D, Beà S, Campo E, Montserrat E. Diffuse large B-cell lymphoma: clinicobiological characterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol 2005; 23(12):2797-804
  • Hernández L, Beà S, Pinyol M, Ott G, Katzenberger T, Rosenwald A, Bosch F, López-Guillermo A, Delabie J, Colomer D, Montserrat E, Campo E. CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus. Cancer Res 2005; 65: 2199-206.
  • Carreras J, Villamor N, Colomo L, Moreno C, Ramón y Cajal S, Crespo M, Tort F, Bosch F, López-Guillermo A, Colomer D, Montserrat E, Campo E. Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms. J Pathol 2005; 205: 507-13.
  • Ferrer A, Marcé S, Bellosillo B, Villamor N, Bosch F, López-Guillermo A, Espinet B, Solé F, Montserrat E, campo E, Colomer D. Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes.Oncogene 2004; 23: 8941-9.
  • Montoto S, López-Guillermo A, Altés A, Perea G, Ferrer A, Camós M, Villela L, Bosch F, Esteve J, Cervantes F, Bladé J, Campo E, Sierra J, Montserrat E. Predictive value of Follicular Lymphoma International Prognostic Index (FLIPI) in patients with follicular lymphoma at first progression. Ann Oncol 2004; 15: 1484-9.
  • Montagut C, Bosch F, Villela L, Rosinol L, Blade J. Aminoglycoside-associated severe renal failure in patients with multiple myeloma treated with thalidomide. Leuk Lymph.2004 Aug;45(8):1711-2
  • Tort F, Camacho E, Bosch F, Lee Harris N, Montserrat E, Campo E. Familial lymphoid neoplasms in patients with mantle cell lymphoma. Haematologica 2004; 89:314-9
  • Martínez A, Bellosillo B, Bosch F, Ferrer A, Marcé S, Villamor N, Ott G, Montserrat E, Campo E, Colomer D. Nuclear survivin expresion in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol 2004; 164:501-510
  • Bosch F, Villamor N. ZAP-70 expression in chronic lymphocytic leukemia: a new parameter for an old disease. Haematologica 2003; 88:724-26.
  • Perea G, Altés A, Montoto S, López-Guillermo A, Bosch F, Jiménez M, Esteve J, Domingo E, Ribera JM, Pedro C, Martino R, Briones J, Sureda A, Brunet S, Sierra J, Montserrat E. International and Italian prognostic indices in follicular lymphoma. Haematologica 2003; 88: 700-4.
  • Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, Marcé BS, López-Guillermo A, Campo E, Monserrat E. ZAP-70 expression as a surrogate for immunoglobulin variable region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764-75. (first and corresponding author)
  • Montoto S, Rozman M, Rosinol L, Nadal E, Gine E, Aymerich M, Ferrer A, Esteve J, Bosch F, Lopez-Guillermo A, Blade J, Montserrat E. Malignant transformation in IgM monoclonal gammopathy of undetermined significance. Semin Oncol 2003 Apr;30(2):178-81
  • Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hemerlink KH, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, Feb; 3:185-197.
  • Colomo L, López-Guillermo A, Perales M, Rives S, Martínez A, Bosch F, Colomer D, Falini B, Montserrat E, Campo E. Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. Blood 2003; 101: 78-84
  • Montoto S, López-Guillermo A, Colomer D, Esteve J, Bosch F, Ferrer A, Villamor N, Moreno C, Campo E, Montserrat E. Incidence and clinical significance of bcl-2/IgH rearrangement in follicular lymphoma. Leuk Lymph 2003; 44: 71-6.
  • Bosch F, Ferrer A, López-Guillermo A, Giné E, Bellosillo B, Villamor N, Colomer D, Cobo F, Perales M, Esteve J, Altés A, Besalduch J, Ribera JM, Montserrat, for the GELCAB (Grup per l’Estudi dels Limfomes de Catalunya i Balears). Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia. Br J Haematol 2002; 119: 976-84.
  • Beà S, López-Guillermo A, Ribas M, Pinyol M, Carrió A, Soler F, Bosch F, Colomer D, Miró R, Montserrat E, Campo E. Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large cell lymphoma (Richter’s syndrome). Am J Pathol 2002; 161: 957-68.
  • Bellosillo B, Villamor N, López-Guillermo A, Marcé S, Bosch F, Campo E, Montserrat E, Colomer D. Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Blood 2002; 100: 1810-6.
  • Giné E, Bosch F, Villamor N, Rozman M, Colomer D, López-Guillermo A, Montserrat E. Simultaneous diagnosis of hairy cell leukemia and chronic lymphocytic leukemia / small lymphocytic lymphoma: a frequent association? Leukemia 2002; 16: 1454-9.
  • Cobo F, Martínez A, Pinyol M, Hernández L, Gómez M, Beà S, Esteve J, Rozman M, Bosch F, López-Guillermo A, Montserrat E, Campo E. Multiple cell cycle regulator alterations in Richter’s transformation of chronic lymphocytic leukemia. Leukemia 2002; 16: 1028-34.
  • Bladé J, Filella X, Montoto S, Bosch F, Rosiñol L, Coca F, Giné E, Nadal E, Aymerich M, Rozman M, Montserrat E. Interleukin 6 and tumor necrosis factor alpha serum levels in monoclonal gammopathy of undetermined significance. Br J Haematol 2002; 117:387-9
  • Montoto S, López-Guillermo A, Ferrer A, Camós M, Álvarez-Larrán A, Bosch F, Bladé J, Cervantes F, Esteve J, Cobo F, Colomer D, Campo E, Montserrat E. Survival after progression in patients with follicular lymphoma: analysis of prognostic factors. Ann Oncol 2002; 13: 523-30.
  • Gallart T, Benito C, Reverter JC, Bosch F, Blay M, Tassies D, Vigorito E, Cervera R, Font J, Gomis R, Campo E, Vives J. True anti-anionic phospholipid immunoglobulin M antibodies can exert lupus anticoagulant activity. Br J Haematol 2002;116:875-86
  • Camacho E, Hernández L, Hernández S, Tort F, Bellosillo B, Beà S, Bosch F, Montserrat E, Cardesa A, Fernández PL, Campo E. ATM gene inactivation in mantle cell lymphoma mainly occur by truncating and missense mutations involving the PI-3 kinase domain. Blood 2002 99: 238-244.
  • Boogaerts MA, Van Hoof A, Catovsky D, Kovacs M, Montillo M, Zinzani PL, Binet JL, Feremans W, Marcus R, Bosch F, Verhoef G, Klein M. Activity of oral fludarabine phosphate in previously treated chronic lymphocytic leukemia. J Clin Oncol 2001; 19: 4252-4258
  • Marti RM, Campo E, Bosch F, Palou J, Estrach T. Cutaneous lymphocyte-associated antigen (CLA) expression in a lymphoblastoid mantle cell lymphoma presenting with skin lesions. Comparison with other clinicopathologic presentations of mantle cell lymphoma. J Cutan Pathol 2001 28:256-64.
  • Migliazza A, Bosch F, Komatsu H, Cayanis E, Martinotti S, Toniato E, Guccione E, Qu X, Chien M, Murty VV, Gaidano G, Inghirami G, Zhang P, Fischer S, Kalachikov SM, Russo J, Edelman I, Efstratiadis A, Dalla-Favera R. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood 2001; 97:2098-104
  • Villela L, López-Guillermo A, Montoto S, Rives S, Bosch F, Perales M, Ferrer A, Esteve J, Colomo L, Campo E, Montserrat E. Prognostic features and outcome in patients with diffuse large B-cell lymphoma who do not achieve a complete response to first-line regimens. Cancer 2001; 91: 1557-62.
  • Sanz-Vaqué, Ll, Colomer D, Bosch F, López-Guillermo A, Dreyling MH, Ott G, Montserrat E, Campo E. Microsatellite instability analysis in typical and progressed mantle cell lymphoma and B-cell chronic lymphocytic leukemia. Haematologica 2001; 86: 181-6..
  • Migliazza A, Cayanis E, Bosch F, et al. Molecular pathogenesis of B-cell chronic lymphocytic leukemia: analysis of 13q14 chromosomal deletions. Curr Top Microbiol Immunol. 2000;252:275-84.
  • Montoto S, Camós M, López-Guillermo A, Bosch F, Cervantes F, Bladé J, Esteve J, Cobo F, Nomdedeu B, Campo E, Montserrat E. Hybrid chemotherapy C-MOPP/ABV as first line treatment in advanced stage Hodgkin’s disease. Cancer 2000; 88: 2142-8.
  • Hernandez L, Hernandez S, Bea S, Pinyol M, Ferrer A, Bosch F, Nadal A, Fernandez PL, Palacin A, Montserrat E, Campo E. c-myc mRNA expression and genomic alterations in mantle cell lymphomas and other nodal non-Hodgkin’s lymphomas. Leukemia. 1999; 13:2087-93.
  • Cobo F, Hernández S, Hernández L, Pinyol M, Bosch F, Esteve J, López-Guillermo A, Palacín A, Raffeld M, Montserrat E, Jaffe ES, Campo E. Expression of potentially oncogenic HHV-8 genes in an EBV-negative primary effusion lymphoma ocurring in an HIV-seronegative patient. J Pathol 1999; 189: 288-93.
  • Terol MJ, López-Guillermo A, Bosch F, Villamor N, Cid MC, Campo E, Montserrat E. Expression of beta-integrin adhesion molecules in non-Hodgkin’s lymphoma: correlation with clinical and evolutive features. J Clin Oncol 1999; 17: 1869-75.
  • Beà S, Ribas M, Hernández JM, Bosch F, Pinyol M, Hernández L, García JL, Flores T, González M, López-Guillermo A, Piris MA, Cardesa A, Montserrat E, Miró R, Campo E. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphomas are associated with blastoid variants. Blood 1999; 93: 4365-74.
  • Geisler C, Hansen MM, Yeap BY, Wiernik P, Binet JL, Chastang C, Dighiero G, Travade P, Jaksic B, Brugiatelli M, Kimby E, Catovsky D, Hamblin T, Richards S, Bosch F, Fontanillas M, Montserrat E, Alison R, Clarke M, Duong H, Elphinstone P, Evans V, Godwin J, Gray R, Greaves E, Hicks C, James S, Mead G, Peto R, Richards S, Wheatley K. Chemotherapeutic Options in Chronic Lymphocytic Leukemia: a Meta-analysis of the Randomized Trials. J Natl Cancer Inst. 1999 May 19;91(10):861-8.
  • Ferrer A, López-Guillermo A, Bosch F, Montoto S, Hernández Boluda JC, Camós M, Miquél R, Campo E, Montserrat E. Linfomas del tejido linfoide asociado a mucosas (MALT) de localización extragástrica: análisis de 14 casos. Med Clin (Barc) 1999; 112: 577-80.
  • Espinet B, Sole F, Woessner S, Bosch F, Florensa L, Campo E, Costa D,Lloveras E, Vila RM, Besses C, Montserrat E, Sans-Sabrafen J. Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma. Cancer Genet Cytogenet 1999; 111:92-8.
  • Blade J, Fernandez-Llama P, Bosch F, Montoliu J, Lens XM, Montoto S, Cases A, Darnell A, Rozman C, Montserrat E. Renal failure in multiple myeloma: presenting features and predictors of outcome in 94 patients from a single institution. Arch Intern Med. 1998; 158: 1889-93
  • López-Guillermo A, Cid J, Salar A, López A, Montalbán C, Castrillo JM, González M, Ribera JM, Brunet S, García-Conde J, Fernández de Sevilla A, Bosch F, Montserrat E. Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the REAL classification. Ann Oncol 1998; 9: 849-55.
  • Sanz L, López-Guillermo A, Martínez C, Bosch F, Esteve J, Cobo F, Montoto S, Perales M, Bladé J, Cervantes F, Campo E, Montserrat E. Risk of relapse and clinico-pathological features in 103 patients with diffuse large-cell lymphoma in complete response after first-line treatment. Eur J Haematol 1998; 61: 59-64.
  • Terol MJ, López-Guillermo A, Bosch F, Villamor N, Cid MC, Rozman C, Campo E, Montserrat E. Expression of the adhesion molecule ICAM-1 (CD54) in non-Hodgkin’s lymphoma. Relationship with tumor dissemination and prognostic importance. J Clin Oncol 1998; 16: 35-40.
  • Targarona EM, Espert JJ, Balague C, Sugranes G, Ayuso C, Lomena F, Bosch F, Trias M. Residual splenic function after laparoscopic splenectomy: a clinical concern. Arch Surg 1998; 133:56-60.
  • Montserrat E, Bosch F, Rozman C. B-cell chronic lymphocytic leukemia: recent progress in biology, diagnosis, and therapy. Ann Oncol. 1997;8 1:93-101
  • Montserrat E, Bosch F, Rozman C. Treatment of B-cell chronic lymphocytic leukaemia: current status and future perspectivas. J Intern Med 242: 63-67 740, 1997
  • Bosch F, López-Guillermo A, Campo E, Ribera JM, Conde E, Piris MA, Vallespi T, Woessner S, Montserrat E. Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors. Cancer 1998; 82: 567-75.
  • Esteve J, Villamor N, Colomer D, Bosch F, López-Guillermo A, Rovira M, Urbano-Ispizua A, Sierra J, Carreras E, Montserrat E. Hematopoietic stem-cell transplantation for chronic lymphocytic leukemia. Report of 12 patients from a single institution. Ann Oncol 1998; 9: 167-72.
  • Rozman C, Bosch F, Montserrat E Chronic lymphocytic leukemia: a changing natural history? Leukemia. 1997 Jun;11(6):775-8.
  • Cervantes F, López-Guillermo A, Bosch F, Terol MJ, Rozman C, Montserrat E. An assessment of the clinicohematological criteria for the accelerated phase of chronic myeloid leukemia. Eur J Haematol 1996; 57: 286-91.
  • Briones J, Montserrat E, Urbano-Ispizua A, Esteve J, Colomer D, López-Guillermo A, Bosch F, Hadjieu E, Rozman C. Tratamiento con fludarabina de neoplasias linfoides de bajo grado de malignidad resistenctes al tratamiento o en recaída. Med Clin 1996; 107: 86-9.
  • Jares P, Campo E, Pinyol M, Bosch F, Miquel R, Fernández PL, Sánchez-Beato M, Soler F, Pérez-Losada A, Nayach I, Mallofré C, Piris MA, Montserrat E, Cardesa A. Expression of retinoblastoma gene product (pRb) in mantle cell lymphoma. Correlation with Cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity. Am J Pathol, 1996; 148(5): 1591-1600.
  • Montserrat E, López-Lorenzo JL, Manso F, Martín A, Prieto E, Arias-Sampedro J, Fernández MN, Oyarzábal FJ, Odriozola J, Alcalà A, García-Conde J, Conde E, Guardia R, Bosch F. Fludarabine in resistant or relapsing B-cell chronic lymphocytic leukemia. The Spanish Group Experience. Leukemia and Lymphoma, 1996; 21:467-472.
  • Montserrat E, Villamor N, Reverter JC, Brugues RM, Tassies D, Bosch F, Aguilar JL, Vives-Corrons JL, Rozman M, Rozman C. Bone marrow assessment in B-cell chronic lymphocytic leukemia: aspirate or biopsy?. A comparative study in 258 patients. Br J Haematol, 1996; 93(1): 111-116.
  • Hernández L, Fest T, Cazorla M, Teruya-Feldstein J, Bosch F, Peinado MA, Piris MA, Montserrat E, Cardesa A, Jaffe ES, Campo E, Raffold M. p53 gene mutations and protein overexpression are associated with agressive variants of mantle cell lymphomas. Blood, 1996; 87(8): 3351-3359.
  • Esteve J, Cervantes F, Bosch F, Cobo F, Montserrat E, Rozman C. Tratamiento con interferón alfa del síndrome hipereosinofílico idiopático resistente a la terapéutica convencional. Med Clin, 1996; 106: 304-306.
  • Montserrat E, Bosch F, López-Guillermo A, Graus F, Terol MJ, Campo E, Rozman C. CNS involvement in mantle-cell lymphoma. J Clin Oncol 1996; 14: 941-4.
  • Bosch F, Campo E, Jares P, Pittaluga S, Muñoz J, Nayach I, Piris MA, DeWolf-Peeters C, Jaffe ES, Rozman C, Montserrat E, Cardesa A. Increased expression of the PRAD-1/CYCLIN D1 gene in hairy cell leukemia. Br J Haematol 1995; 91(4): 1025-1030.
  • Esteve J, López-Guillermo A, Martínez-Francés A, Bosch F, Terol MJ, Campo E, Montserrat E, Rozman C. Presenting features, natural history, and prognostic factors in localized non-Hodgkin’s lymphomas: analysis of 117 cases from a single institution. Eur J Haematol 1995; 55: 217-222.
  • Fraga M, Lloret E, Sánchez-Verde L, Orrade JL, Campo E, Bosch F, Piris MA. Mucosal mantle (centrocytic) lymphomas. Histopathology, 1995; 26: 413-422.
  • Martínez – Francés A; López – Guillermo A; Esteve J; Bosch F; Terol MJ; Montserrat E. Characteristics of patients with low grade malignant lymphoma and long survival. Sangre (Barc). 1995 Feb;40(1):53-7.
  • Bosch F, Jares P, Campo E, López-Guillermo A, Villamor N, Tassies D, Piris MA, Jaffe ES, Montserrat E, Rozman C, Cardesa A. PRAD-1/Cyclin D1 overexpression in lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma. Blood 1994; 84(8): 2726-2732.
  • Bladé J, López-Guillermo A, Bosch F, Cervantes F, Reverter JC, Montserrat E, Rozman C. Impact of response to treatment on survival in multiple myeloma: results in a series of 243 patients. Br J Haematol 1994; 88: 117-21.
  • López-Guillermo A, Montserrat E, Bosch F, Escoda L, Terol MJ, Marín P, Reverter JC, Bladé J, Cervantes F, Sierra J, Rovira M, Nomdedeu B, Urbano-Ispizua A, Carreras E, Campo E, Rozman C. Low-grade lymphomas: clinical and prognostic studies in a series of 143 patients from a single institution. Leuk Lymph 1994; 15: 159-65.
  • Jares P, Fernández PL, Campo E, Nadal A, Bosch F, Aiza G, Nayach I, Traserra J, Cardesa A. PRAD1/Cyclin D1 gene amplification correlates with mRNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res 1994; 54: 4813-4817.
  • López-Guillermo A, Montserrat E, Bosch F, Terol MJ, Campo E, Rozman C. Applicability of the International Index for aggressive lymphomas to patients with low-grade lymphoma. J Clin Oncol 1994; 12: 1343-8.
  • Campo E, Miquel R, Jares P, Bosch F, Juan M, Leone A, Vives J, Cardesa A, Yagüe J. Prognostic significance of the loss of heterozygosity of Nm23-H1 and p53 genes in human colorrectal carcinomas. Cancer 1994; 73: 2913-2921.
  • Villamor N, Marín P, Aymerich M, Arriols R, Rovira M, Bosch F, Vilella R, Rozman C, Vives-Corrons JL. Diagnóstico de la hemoglobinuria paroxística nocturna mediante el análisis citofluorimétrico de moléculas unidas a membrana por grupos glucosilfosfatidilinositol. Med Clin 1994; 102: 481-484.
  • Cervantes F, Urbano-Ispízua A, Pujades A, Bosch F, Vives-Corrons JL, Montserrat E, Rozman C. Análisis molecular en la leucemia mieloide crónica cromosoma Filadelfia negativa: estudio de seis casos. Med Clin 1992; 99: 286-288
  • Sierra J, Grañena A, Bosch F, Carreras E, Martí JM, Urbano-Ispízua A, Rovira M, Rozman C. Mitoxantrone and intermediate-dose cytosine arabinoside for poor-risk acute leukemias: response to treatment and factors influencing outcome. Hematol Oncol 1992; 10: 301-309.
  1. Project title: Exploración y prueba de concepto de la eficacia del tratamiento combinado con Ory-1001 en indicaciones oncológicas (COMBO-EPoC).
    Duration: 01/01/2018 – 31/03/2021.
    Funding entity: MINECO-RETOS
    PI: Francesc Bosch.
  2. Project title: Uso de linfocitos T específicos third partycontra antígenos virales, procedentes de un registro de donantes voluntarios, para el tratamiento de infecciones por CMV, VEB y adenovirus.
    Duration: 01/01/2017 – 30/06/2021.
    Funding entity: FIS-ISCIII.
    PI: Pere Barba.
  3. Project title: Estudio funcional del sistema inmune (SI) en síndromes mielodisplásicos (SMD) según el perfil mutacional. Influencia de las alteraciones evolutivas del SI en la progresión del SMD.
    Duration: 01/01/2018 – 01/07/2021.
    Funding entity: FIS-ISCIII.
    PI: David Valcarcel
  4. Project title: Patogénesis y nuevas dianas moleculares en sindromes linfoproliferativos.
    Duration: 01/12/2013 – 31/12/2021.
    Funding entity: MINECO-RyC (MINECO Ramón y Cajal).
    PI: Marta Crespo.
  5. Project title: Papel de la vigilancia y evasión inmune en la fisiopatología y inmunoterapia de los linfomas del sistema nervioso central.
    Duration: 01/01/2018 – 01/01/2022.
    Funding entity: FIS-ISCIII.
    PI: Marta Crespo.
  6. Project title: Optimización del uso de inhibidores de checkpoint en pacientes con neoplasias linfoides que reciben un trasplante alogénico de progenitores hematopoyético.
    Duration: 01/08/2019 – 01/03/2022.
    Funding entity: Fundación Científica de la Asociación Española Contra el Cáncer.
    PI: Pere Barba.
  7. Project title: Macrophage-mediated immunotherapy optimization in lymphomas affecting the central nervous system.
    Duration: 01/11/2018 – 31/10/2022.
    Funding entity: Fundación Científica de la Asociación Española Contra el Cáncer.
    PI: Marta Crespo.
  8. Project title: Predicción de la respuesta a lusparceptept en los síndromes mielodiplásicos: análisis de la diferenciación eritroide terminal mediante un sist. ex vivo y RNA seq.
    Duration: 01/03/2018 – 31/12/2022.
    Funding entity: Fundación Española de Hematología y Hemoterapía.
    PI: Francesc Bosch.
  9. Project title: Inhibición de la proteína quinasa ZAP-70 como terapia dirigida en linfomas T periféricos.
    Duration: 01/01/2019 – 31/12/2022.
    Funding entity: FIS-ISCIII.
    PI: Pau Abrisqueta.
  10. Project title: Estudi i implicacions translacionals de l’evasió del sistema immunitari en la leucèmia limfàtica crónica.
    Duration: 01/06/2020 – 12/07/2023.
    Funding entity: MARATÓ TV3.
    PI: Francesc Bosch.
  11. Project title: Red cooperativa franco-española para el análisis de proteinopatías y el desarrollo de terapias individualizadas en cánceres hematológicos
    Duration: 01/06/2019 – 31/12/2023.
    PI: David Valcarcel.
  12. PROTEOBlood Project. Recent advances in the diagnosis and selective treatment of some blood cancers have made significant advances in treatment towards curing the disease, but unfortunately some of these cancers remain incurable, with much evidence suggesting a link between imbalances in protein homeostasis and the development of some subtypes of leukemia and lymphoma. The study of protein homeostasis in the area of ​​hematology-oncology requires highly specialized knowledge and significant investment in cutting-edge technology and infrastructure.The economic and knowledge challenge that this area in constant evolution represents has motivated the collaboration between different parties involved for the development of the PROTEOblood project and financed with ERDF funds, which brings together a set of laboratories and research teams with the necessary experience and knowledge of specialized technological platforms that will allow progress in the search for treatments.Thus, PROTEOblood will promote technological development in the area of ​​proteinopathies and their application in the treatment of leukemia and lymphoma. PROTEOblood will strengthen cross-border cooperation in the field of protein homeostasis by 1) developing new study models optimized for proteomic profiling and more in line with the biology of these tumors than current models, and 2) designing a new class of therapeutic compounds specifically targeting the identified proteinopathies, using pioneering systems biology and computational chemistry approaches. PROTEOblood will thus promote innovation and its applicability in the POCTEFA region.Coordinated by Dr. Gaël Roué of the Josep Carreras Leukemia Research Institute, the PROTEOBlood project involves researchers from the Experimental Hematology Group of the Vall d’Hebron Institute of Oncology (VHIO); from the GQF Pharmaceutical Chemistry Group of the Sarriá Chemical Institute (IQS); from the Institute of Health and Medical Research – INSERM; from the Association Center for Cooperative Research in Biosciences – CICbioGUNE; from the Occitanie West branch of the French National Center for Science Research – CNRS; and the Spanish biotech company Anaxomics Biotech.

VHIO contribution

Optimization of existing PDX generation processes in VHIO laboratories through technological exchange. VHIO will share its know-how for creating 3D culture models by associating AML and DLCG cells with stromal cells loaded with gold nanoshuttle and grown on hydrogels. Collections of 3D organoids and PDX of 40 AML and LDCG patients will be generated with clinical-biological information and the genetic profile of the patients. On the other hand, VHIO will also participate in the design of new molecules with antitumor activity, collaborating in the creation of a library of small molecules directed towards Ub and Ub-like proteins (IQS) and studies of efficacy and mechanisms of action in preclinical models of LAM and LDCG.

Realization period: 01/06/2019 – 31/05/2022

Principal Investigator of the project at VHIO: David Valcárcel

Contact: dvalcarcel@vhio.net

Other websites of interest:

www.poctefa.eu

ec.europa.eu/regional_policy/en/

 

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